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  1. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 12 (also presented at TSRC 2023)

    Rapid in vitro toxicological screening using ToxTracker to determine the effect of repeated freeze/thaw of combustible cigarette extract

    CARMINES E.(2); MISRA M.(2); OH S.(1); HENDRIK G.(3); COFFA B.G.(1,2); ALEKSA K.(1)
    (1) Labstat International, Kitchener, ON, Canada; (2) Chemular Inc., Hudson MI, U.S.A.; (3) Toxys Inc., CG Leiden, The Netherlands
    Combustible cigarette extracts (CCE) are stored at -80 °C to preserve sample integrity. Sample shipping and repeated freeze/thaw cycles prior to testing may lead to changes in the chemical composition through the formation of ice-water...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 13

    Application of rapid in vitro toxicological screening using ToxTracker to determine the effect of flavors in snus products.

    CARMINES E.(2); MISRA M.(2); OH S.(1); HENDRIK G.(3); COFFA B.G.(1,2); ALEKSA K.(1)
    (1) Labstat International, Kitchener, ON, Canada; (2) Chemular Inc., Hudson MI, U.S.A.; (3) Toxys Inc., CG Leiden, The Netherlands
    Snus is an oral tobacco derived nicotine product that is sold in flavored pre-packages. Snus is traditionally sold as tobacco flavored. The potential impact of flavors on toxicity is unknown. Regulatory assays such as Ames, neutral red uptake (NRU),...
  3. TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 98 (also presented at CORESTA SSPT2023)

    Rapid in vitro toxicological screening using toxtracker to determine the effect of repeated freeze/thaw of combustible cigarette extract

    ALEKSA K.(1); OH S.(1); CARMINES E.(2); MISRA M.(2); COFFA B.(2); HENDRIKS G.(3)
    (1) Labstat International Inc., Kitchener, ON, Canada; (2) Chemular Inc., Hudson MI, USA; (3) Toxys, Leiden, Netherlands
    Combustible cigarette extracts (CCE) are stored at -80°C to preserve sample integrity. Sample shipping and repeated freeze/thaw cycles prior to testing may lead to changes in the chemical composition through the formation of ice-water interfaces,...
  4. TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 99

    Application of a rapid in vitro toxicological screening (ToxTracker©) to determine the effect of flavors in snus products

    CARMINES E.(1); ALEKSA K.(2); OH S.(2); MISRA M.(1); COFFA B.(1); HENDRIKS G.(3)
    (1) Chemular Inc., Hudson MI, USA, (2) Labstat International Inc., Kitchener, ON, Canada; (3) Toxys, Leiden, Netherlands
    Snus is an oral tobacco derived nicotine product that is sold in flavored pre-packages. Snus is traditionally sold as tobacco flavored. The potential impact of flavors on toxicity is unknown. Regulatory assays such as Ames, neutral red uptake (NRU),...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 25

    Misperception of e-cigarette harm growing among American adults, 2013-2015

    VERRON T.(1); GUO M.(1); VARIGNON B.(1); O'CONNELL G.(2); WALELE T.(2); CAHOURS X.(1)
    (1) SEITA - Imperial Brands plc, Paris, France; (2) Fontem Ventures B.V., Amsterdam, The Netherlands
    Electronic cigarettes (e cigarettes) have been characterised as significantly less harmful than smoked tobacco by an increasing number of public health authorities. However, the proportion of American adults who perceive e cigarettes to be equally or...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 39

    The use of high content screening (HCS) in human primary lung cells to assess e-liquids of differing flavors and nicotine concentrations

    SIMMS L.(1); CZEKALA L.(1); STEVENSON M.(1); PHILLIPS G.(1); WALELE T.(2)
    (1) Imperial Brands, Bristol, U.K.; (2) Fontem Ventures, Amsterdam, The Netherlands
    Due to the current scientific debate and evolving regulatory landscape, new assays are needed to quickly determine the subtle biological response of e-liquids for both stewardship and product development purposes. For stewardship, all ingredients in...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 52

    Biological test procedure for fresh generated cigarette smoke and e-cigarette aerosols under air-liquid interface (ALI) exposure in 24 and 96 multi-well plates

    WIECZOREK R.(1); TRELLES STICKEN E.(1); WALELE T.(2); CZEKALA L.(3); SIMMS L.(3)
    (1) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (2) Fontem Ventures, Amsterdam, The Netherlands; (3) Imperial Tobacco Limited, Bristol, U.K.
    Cigarette smoke and e cigarette aerosol contain particulate matter/liquid droplets in the solid phase as well as volatile substances in the gas phase. Both fractions are of potential toxicological relevance and should be considered when assessing...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 53

    Use of human derived cell lines to increase the biological relevance of cigarette condensate, non-tobacco materials and e-liquids testing

    WIECZOREK R.(1); TRELLES STICKEN E.(1); WALELE T.(2); CZEKALA L.(3); SIMMS L.(3)
    (1) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (2) Fontem Ventures, Amsterdam, The Netherlands; (3) Imperial Tobacco Limited, Bristol, U.K.
    The in vitro testing strategy of tobacco products is mainly based on the testing of extracts from cigarette smoke condensates. An accepted industry wide assay battery has been developed over recent years which delivers reliable results for the...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 044

    Comparative measurements of puff aerosol size and concentration of combustion, heated tobacco, and liquid e-cigarettes by light scattering method

    HOLVE D.J.(1); HOORNSTRA J.(2)
    (1) Envirometrix Instruments LLC, Berkeley, CA, USA; (2) Envirometrix Instruments LLC, Sint Maartensbrug, Netherlands
    In a previous presentation at the 2015 TSRC, the development and application of a new light scattering instrument based on Mie theory (Orion-A) was presented (ref 1). Further developments and improvements have been implemented on the Orion...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 22

    Estimation of e-cigarette aerosol yields based on puff duration

    JULIEN R.(1); TSCHIERSKE N.(2); VARIGNON B.(1); TROUDE V.(1); DESTRUHAUT S.(1); WALELE T.(3); COLARD S.(1); CAHOURS X.(1)
    (1) SEITA-Imperial Tobacco Limited, Fleury-les-Aubrais, France; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    There are regulatory requirements in quantifying and comparing the emission levels of major and minor aerosol constituents from e-cigarettes. Up until the recent publication in 2015 of CORESTA Recommended Method (CRM) No. 81 - "Routine Analytical...