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131 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2023, Cancun, APPOST 07

    Chromosome-level genomes of the Nicotiana tabacum progenitors, Nicotiana sylvestris and Nicotiana tomentosiformis

    SIERRO N.; OUADI S.; AUBERSON M.; DULIZE R.; GUEDJ E.; IVANOV N.V.; GOEPFERT S.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    As descendants of the Nicotiana tabacum progenitors, Nicotiana sylvestris and Nicotiana tomentosiformis are important diploid Nicotiana species. In addition, ancestors of N. sylvestris were involved in the polyploidization events that gave rise...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, CROM 00

    Science starts with measurement: essential measurement science for self-report in tobacco and nicotine product research

    McCAFFREY(1); MOREAN M.(2); AFOLALU E.(3); BLACK R.(1); SHIFFMAN S.(4); SARKAR M.(5)
    (1) Juul Labs Inc., Washington DC, U.S.A.; (2) Yale School of Medicine, New Haven, CT, U.S.A.; (3) Philip Morris Products S.A., Neuchatel, Switzerland; (4) Pinney Associates, Inc., Bethesda, MD, U.S.A.; (5) Altria Client Services LLC, Richmond, VA, U.S.A.
    Consumer reported outcome measures (CROM) are a critical component of tobacco regulatory science. Examples of CROM include measures of tobacco product dependence and risk perceptions. Like other fields of science, behavioral researchers require...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, CROM 04

    Further validation of the ABOUT-Dependence measure: Extending assessment of perceived dependence on tobacco and nicotine products to users of a heated tobacco product (IQOS)

    AFOLALU E.
    Philip Morris Products S.A., Neuchâtel, Switzerland
    The ABOUT™–Dependence is a Consumer Reported Outcomes Measure (CROM) developed to assess perceived dependence associated with tobacco and/or nicotine product (TNP) use. It was developed and validated in US English for TNP users who were either...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, NAM 05

    COPD AOP-I: quantitative modeling of in vitro data using an adverse outcome pathway for the assessment of decreased lung function risk in humans

    TALIKKA M.; ISKANDER A.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Adverse outcome pathways (AOPs) organize mechanistic knowledge based on empirical evidence into a sequence of cell, tissue, and organ level events that lead to an adverse outcome (AO) in humans. An AOP initiates from the interaction of a stressor...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, ST 35

    Heating vs. burning: a non-targeted analytical characterization of compounds with higher abundance in the aerosol of a heated tobacco product than in mainstream cigarette smoke

    LANG G.; ALMSTETTER M.; ARNDT D.; HENAO C.; GOUJON-GINGLINGER C.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Heated tobacco product (HTP) aerosols have been shown to contain—on average—lower levels of known harmful or potentially harmful constituents (HPHCs) than smoke from conventional cigarettes. However, few studies have investigated the chemical...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, ST 37

    Quantitation of selected elements in the aerosol of electrically heated tobacco products (eHTPs) by inductively coupled plasma mass spectrometry (ICP-MS)

    O’REILLY C.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Metals are among the most ubiquitous environmental contaminants and can enter the tobacco plant through various sources including soil adsorption and fertilizer application. Additional sources of trace levels of metals present in tobacco can be due...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 01

    Statistical derivation of a fold-change cut-off for non-targeted differential screening studies based on analytical method variability

    KLEINHANS S.; LANG G.; GOUJON-GINGLINGER C.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Chemical characterization of smoke-free products relies on both validated quantitative methods for specific analytes and screening methods such as non-targeted differential screening (NTDS). The latter approach identifies compositional differences...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 06

    Validation of extraction method for tobacco-free nicotine pouches and Swedish snus pouch products - towards standardization of in vitro testing

    TALIKKA M.; GORALCZYK A.; DOS SANTOS D.; ALRIQUET M.; ZANETTI F.; ORTEGA TORRES L.; PAK C.; BERTHOUZOZ M.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Tobacco-free nicotine pouches (NP) and tobacco-containing Swedish snus pouches (Swedish snus) are two types of nicotine-delivery products for oral use. A standard method to generate an extract of these products for in vitro testing has not been...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, STPOST 30

    Comparison of material surface staining following exposure to heated tobacco and e-vapour aerosols versus cigarette smoke

    GOMEZ LUESO M.; RODRIGUES CRESPO K.; GLABASNIA A.; GOUJON-GINGLINGER C.; KLEINHANS S.; MITOVA M.I.; LANG G.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Cigarette smoke deposition on indoor surfaces leads to discoloration, particularly for light-coloured materials. The less complex aerosols emitted by heated tobacco products (HTPs) and e-vapor products (EVPs) contain ≥ 90 % water and...