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211 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 39

    Addressing U.S. FDA’s population health standard for Camel Snus with modified risk messaging

    CURTIN G.(1); BACHAND A.(2); SULSKY S.(2); GERLACH K.(3); PILLITTERI J.(4); SHIFFMAN S.(3)
    (1) RAI Services Co., Winston-Salem, NC, U.S.A.; (2) Ramboll Environ US Corp., Amherst, MA, U.S.A.; (3) Pinney Associates, Inc., Pittsburgh, PA, U.S.A.; (4) Pinney Associates, Inc., Burlington, VT, U.S.A.
    R.J. Reynolds Tobacco Company has submitted Modified Risk Tobacco Product applications to the U.S. Food and Drug Administration seeking risk modification orders for Camel Snus advertising, which includes information that smokers who switch completely to ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 40

    FDA’s proposed NNN product standard: review of the scientific evidence

    MARANO K.M.(1); BACHAND A.(2); LIU C.(1); SULSKY S.(2); MARIANO G.(2); CURTIN G.M.(1); PARMS T.(1); GREEN T.(3); GENTRY P.R.(3)
    (1) RAI Services Co., Winston-Salem, NC, U.S.A.; (2) Ramboll Environ US Corp., Amherst, MA, U.S.A.; (3) Ramboll Environ, Monroe, LA, U.S.A.
    The U.S. Food and Drug Administration (FDA) has published a proposed standard of 1 µg/g (dry weight) N-nitrosonornicotine (NNN) in finished smokeless tobacco products. FDA’s rationale for the standard is that NNN is a potent carcinogen, NNN is a major ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 63 (also presented at TSRC 2017)

    A computational model to characterize the Vitrocell® Cell Exposure System for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.(1); KUCZAJ A.(2,3); LUCCI F.(2); OLDHAM M.J.(1); PITHAWALLA Y.B.(1)
    (1) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Multiscale Modeling and Simulation, Faculty EEMCS, University of Twente, Enschede, The Netherlands
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL ® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant to e ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 02

    Analysis of 20 elements in aerosols by inductively coupled plasma mass spectrometry (ICP-MS)

    GREMAUD M.; HOFER I.; MARCHESE A.; SEQUEIRA C.; LE BOUHELLEC S.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Metals are present in the aerosol of tobacco products and are known as harmful or potentially harmful compounds. The purpose of this study was to improve and re-validate an existing method for the determination of elements in smoke from cigarettes and in ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 26

    How do consumers use the candidate modified risk tobacco product (MRTP) tobacco heating system (THS): analysis of data from six countries

    ROULET S.(1); MAGNANI P.(1); KALLISCHNIGG G.(2); BADOGLIO S.(1); ACKERMANN K.(3); VEIT M.(3); DUGAN A.(4); GAGE C.(4); KANITSCHEIDER C.(5); APECECHEA M.(5); RAMAZZOTTI A.(1)
    (1) Philip Morris International Management S.A. (PMI), Lausanne, Switzerland; (2) ARGUS – Statistics and Information Systems in Environment and Public Health, Berlin, Germany; (3) FehrAdvice & Partners, Zurich, Switzerland; (4) Kantar Health LLC, New York, U.S.A.; (5) Kantar Health GmbH, Munich, Germany
    PMI conducted consumer studies in several countries for a candidate MRTP, the THS. THS is composed of a tobacco heating device which heats specially designed tobacco sticks. The purpose of these studies was to investigate how adult daily smokers actually ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 31

    Psychometric evaluation of the mCEQ applied to cigarettes and heat-not-burn products in the U.S. and Japan

    SALZBERGER T.(1); CANO S.(2); MAINY N.(3); CHREA C.(3); VANDYKE S.(3); HAZIZA C.(3); WEITKUNAT R.(3); ROSE J.(4)
    (1) University of Economics and Business, Vienna, Austria; (2) Scale Report, Stotfold, U.K.; (3) Philip Morris Products S.A., Neuchatel, Switzerland; (4) Rose Research Center, Raleigh, U.S.A.
    The modified Cigarette Evaluation Questionnaire (mCEQ) is a self-report instrument that assesses the reinforcing effects of smoking cigarettes from a smoker’s perspective. Conceptually, the mCEQ consists of three multi-item and two single-item domains. ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 32

    Assessment of the total volatile organic compounds in indoor air during the use of a new heat-not-burn product

    THARIN M.; BIELIK N.; ROUGET E; ROTACH M.; GLABASNIA A.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    PMI is developing products that have the potential to present less risk of harm to smokers who switch to these products versus continued smoking. The tobacco heating system (THS) is one of these products based on a technology that heats the tobacco ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 37

    FDA’s proposed NNN product standard: quantitative risk assessment

    MARANO K.M.(1); GENTRY P.R.(2); LIU C.(1)
    (1) RAI Services Co., Winston-Salem, NC, U.S.A.; (2) Ramboll Environ, Monroe, LA, U.S.A.
    The U.S. Food and Drug Administration (FDA) has published a proposed standard for N-nitrosonornicotine (NNN) content in finished smokeless tobacco products. The proposed NNN limit of 1 part per million (ppm) dry weight was derived based on a target excess ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 38

    FDA’s proposed NNN product standard: toxicological evidence review

    MARANO K.M.(1); GREEN T.(2) GENTRY P.R.(2)
    (1) RAI Services Co., Winston-Salem, NC, U.S.A.; (2) Ramboll Environ, Monroe, LA, U.S.A.
    The U.S. Food and Drug Administration (FDA) has published a proposed standard for N-nitrosonornicotine (NNN) in smokeless tobacco products. An independent review of the toxicological evidence was conducted, and results of this review suggested that FDA ...