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242 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 03

    Determination of nicotine, eugenol, menthol and aerosol formers in tobacco products and materials

    BELLO J.; D’AGOSTINO A.; JUVET-PECALVEL C.; NAGANATHAN K.; ROTA C.; GAUTIER L.; O’REILLY C.; DUPASQUIER N.; YERLY M.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    The purpose of this study was to validate a unique method that simultaneously determines the concentration of nicotine, eugenol, menthol, and glycerin in Reduced-Risk Products tobacco products [1], and menthol and triacetin in materials. Analytes are ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the whole ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 48

    Six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of two reduced risk tobacco products compared with conventional cigarettes

    PHILLIPS B.(2); SZOSTAK J.(1); HO J.(2); GUEDJ E.(1); WONG Ee Tsin(2); TALIKKA M.(1); LEBRUN S.(1); TITZ B.(1); MARTIN F.(1); VUILLAUME G.(1); LEROY P.(1); IVANOV N.(1); VANSCHEEUWIJCK P.(1); PEITSCH M.C.(1); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Philip Morris International Research Laboratories Pte. Ltd., (part of Philip Morris International group of companies), PMI R&D, Singapore
    Cigarette smoking causes adverse health effects that may occur shortly after smoking initiation and lead to the development of cardiovascular disease, respiratory disease (chronic obstructive pulmonary disease), and various cancers. To reduce the risk of ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 54

    Patterns of use behaviors in a sample of Japanese heat-not-burn tobacco product (IQOS) users

    AFOLALU E.F.; LANGER P.; PRIETO L.; SKIADA D.; DOBRYNINA M.; SPONSIELLO-WANG Z.; WEITKUNAT R.; LÜDICKE F.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Innovative tobacco products are being developed with the potential to advance tobacco harm reduction efforts and reduce the risk of smoking-related diseases. Their potential beneficial public health impact depends upon smokers’ acceptance to switch to ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 58

    Developing fit-for-purpose self-report instruments for assessing consumer responses to tobacco and nicotine products: the ABOUT Toolbox initiative

    CHREA C.(1); SPIES E.(1); AFOLALU E.F.(1); MAINY N.(1); GALLOT S.(1); BINGGELI P.(1); CLERC E.(1); WEITKUNAT R.(1); SALZBERGER T.(2); CANO S.(3); ACQUADRO C.(4); ARNOULD B.(4); LAMBERT J.(4); BRUNEL V.(4); MARCUCCILLI C.(4); ABETZ-WEBB L.(5); ROSE J.(5); FAGERSTRÖM K.(5)
    (1) Philip Morris Products S.A.(part of Philip Morris International group of companies), Neuchâtel, Switzerland; (2) University of Economics and Business, Vienna, Austria; (3) ScaleReport, Ltd, Stotfold, U.K.; (4) Mapi, an ICON plc Company, Lyon, France; (5) Patient-Centered Outcomes Assessments, Ltd, Macclesfield, Cheshire, U.K.; (6) Rose Research Center, Raleigh, NC, U.S.A.; (7) K. Fagerström Consulting AB, Vaxholm, Sweden
    Assessing the full potential of reduced risk products (RRP), for individual users and the population as a whole, requires the assessment of consumer perception and behavior associated with tobacco and nicotine products (TNP) with different exposure and ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 61

    A 6-month inhalation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke

    WONG Ee Tsin(1); SZOSTAK J.(2); KRISHNAN S.(1); TAN Wei Teck(1); SEOW E.(1); TENG C.(1); LEE K.M.(3); ZHANG Jingjie(3); McKINNEY W.J.(3); PEITSCH M.C.(2); VANSCHEEUWIJCK P.(2); HOENG J.(2)
    (1) Philip Morris International Research Laboratories Pte. Ltd., (part of Philip Morris International group of companies), PMI R&D, Singapore; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Altria Client Services LLC, Richmond, VA, U.S.A.
    Chronic exposure to cigarette smoke is a risk factor for the development and progression of cardiovascular disease and chronic obstructive pulmonary disease. Considerable attention has been given towards the potential reduced harm of e cigarettes (e cigs) ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 32

    Consumers’ responses to communication materials of a novel heat-not-burn tobacco product

    CHREA C.(1); KALLISCHNIGG G.(2); SANDERS E.(3); BEACHER F.(4); MAGNANI P.(4); RAMAZZOTTI A.(4); WEITKUNAT R.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) ARGUS – Statistics and Information Systems in Environment and Public Health GmbH, Berlin, Germany; (3) Edward Sanders Scientific Consulting, Peseux, Switzerland; (4) Philip Morris International Management S.A. (PMI) (part of Philip Morris International group of companies), Lausanne, Switzerland
    Modified risk tobacco products (MRTPs) are defined by the U.S. Food and Drug Administration (FDA) as tobacco products that are sold or distributed for use to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 33

    Air quality assessment during indoor use of the Tobacco Heating System 2.2

    MITOVA M.; GOUJON GINGLINGER C.; ROTACH M.; MAEDER S.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    PMI’s heat-not-burn Tobacco Heating System 2.2 (THS 2.2) generates tobacco aerosol containing mainly water, glycerine and nicotine. To address public health concerns about the possible presence of polluting substances during indoor use of THS 2.2, a study ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 63 (also presented at TSRC 2017)

    A computational model to characterize the Vitrocell® Cell Exposure System for evaluation of aerosols

    CASTRO N.(1); ROSTAMI A.(1); KUCZAJ A.(2,3); LUCCI F.(2); OLDHAM M.J.(1); PITHAWALLA Y.B.(1)
    (1) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Multiscale Modeling and Simulation, Faculty EEMCS, University of Twente, Enschede, The Netherlands
    In vitro exposure systems can be used as tools for toxicological assessment of e-cigarette aerosols. The VITROCELL ® exposure system is designed such that exposure of cell cultures to the aerosol occurs at the air/liquid interface, which is relevant to e ...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 02

    Analysis of 20 elements in aerosols by inductively coupled plasma mass spectrometry (ICP-MS)

    GREMAUD M.; HOFER I.; MARCHESE A.; SEQUEIRA C.; LE BOUHELLEC S.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Metals are present in the aerosol of tobacco products and are known as harmful or potentially harmful compounds. The purpose of this study was to improve and re-validate an existing method for the determination of elements in smoke from cigarettes and in ...