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185 results

  1. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 20

    Evaluation of a biomarker of oxidative stress: the 8-iso prostaglandin F2α: prostaglandin F2α ratio in human plasma

    MILLER P.(1); NEWLAND K.(1); DZERK A.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    F2-isoprostanes have been widely studied as biomarkers of oxidative stress for various indications, including smoking. Since both enzymatic biosynthesis and chemical lipid peroxidation can generate these biomarkers, there are various interpretations that ...
  2. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 62

    FTIR method for e-cigarette aerosol characterization

    RADTKE F.; SUSZ A.; MONNI R.; STOOP A.; VERBEECK J.; MAEDER S.
    Philip Morris International, Research & Development, Philip Morris Products S.A., Neuchâtel, Switzerland
    The global electronic cigarettes (e-cig) market and product variety is expected to continue growing over the next years. This growth is being accompanied with interest in methods to compare different products for many reasons, including potential future ...
  3. CORESTA Meeting, Agronomy/Phytopathology, 2015, Izmir, Turkey, APW 02

    The tobacco genome sequence

    SIERRO N.; BATTEY J.N.D.; OUADI S.; BAKAHER N.; BOVET L.; WILLIG A.; GOEPFERT S.; PEITSCH M.C.; IVANOV N.V.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences have been available until recently. The three most commonly used tobacco types are flue-cured (or Virginia), Burley and ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, ST 14

    The influence of slim cigarette market share on smoking prevalence

    SLATER A.(1); BUSS J.(1); GHOSH D.(2)
    (1) Oxford Economics Ltd, Oxford, U.K.; (2) Philip Morris International, Lausanne, Switzerland
    Slim cigarettes were defined in the 2012 draft EU-Tobacco Product Directive (EU-TPD) as cigarettes with a diameter of less than 7.5mm. Slim cigarettes are marketed in various countries around the world and have been growing as a share of the global ...
  5. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 54

    Indoor air chemistry (IAC): comparative study between conventional cigarette and heat-not-burn technology

    GOUJON C.; MAEDER S.
    Philip Morris International R&D, Neuchâtel, Switzerland
    Philip Morris International (PMI) is developing products with the potential to reduce the risk associated with smoking. The Electrically Heated Tobacco System (EHTS) operates by heating a tobacco stick with a holder at a controlled temperature. By heating ...
  6. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 78

    Predictability of in vitro toxicological assessments of cigarettes: analysis of seven years of regulatory submissions to Canadian authorities

    BELUSHKIN M.(1); PIADÉ J-J.(1); CHAPMAN S.(2); FAZEKAS G.(2)
    (1) Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Rothmans, Benson & Hedges Inc., Brampton, Ontario, Canada
    Canadian authorities have required the annual submission of a wealth of by-brand information about cigarettes – including analytical data for cut filler and mainstream smoke constituents, for more than a decade. In 2005, the reporting requirements were ...
  7. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 21

    Evaluating the genotoxicity of tobacco smoke-derived aerosols using the flow cytometry-based in vitro micronucleus assay

    POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The in vitro micronucleus (MN) assay is used to assess the genotoxic potential of a test substance by measuring the induction of micronuclei in cultured mammalian cells. The flow cytometry-based assay (in vitro MicroFlow ® kit, Litron Laboratories, USA) ...
  8. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 23

    Quantitative evaluation of the mutagenicity induced by tobacco smoke-derived total particulate matter using the mouse lymphoma assay

    DEMOUTE A-L.; AL-JOBORI O.; POULEAU B.; SMART D.J.; McHUGH D.
    Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The mouse lymphoma assay (MLA) is a regulatory in vitro test deployed to evaluate the mutagenicity of a test substance via exposure of the thymidine kinase locus in L5178Y mouse lymphoma cells. As part of a proficiency study, we evaluated the mutagenicity ...