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181 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 04

    A modified Cambridge filter holder and extraction equipment and methodology to more accurately quantify water in high water content aerosols

    GHOSH D.; JEANNET C.
    Philip Morris International, Research & Development, Neuchâtel, Switzerland
    Philip Morris International is developing products with the potential to reduce the risk of smoking-related diseases by heating tobacco and avoiding combustion. The resulting aerosol has a less complex chemical composition and contains more water than ...
  2. CORESTA Congress, Sapporo, 2012, Plenary Session, abstr. IG 02

    Levels of tobacco-specific N-nitrosamines NNN and NNK in commercial cigarettes sampled in2008-2010 – A review of analytical data

    GUNDUZ I.(1); KONDYLIS A.(1); HOFER R.(1); JACCARD G.(2); RUFFIEUX L.(3); GADANI F.(1)
    (1) Philip Morris Products SA, Product Development – Applied Cigarette Research, Neuchatel, Switzerland; (2) Philip Morris International Management SA, Product and Process Quality, Neuchatel, Switzerland; (3) Philip Morris International Management SA, Agricultural Programs, Lausanne, Switzerland
    The present study was designed to determine levels of the tobacco-specific N-nitrosamines (TSNAs) N’-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in tobacco cut filler and in mainstream smoke of commercial cigarette ...
  3. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 05

    Impact of cigarette paper properties on smoke constituents’ delivery under Health Canada Intense smoking regime

    GUYARD A.; MEIER D.; CECCHETTO A.; HOFER R.; LI P.
    Philip Morris Products SA, Product Development – Applied Cigarette Research, Neuchatel, Switzerland
    This investigation was undertaken to assess to which extent the changes of cigarette paper characteristics may impact the delivery of nine cigarette smoke constituents when measured under Health Canada Intense (HCI) smoking regime and normalised to smoke ...
  4. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 07

    Improved methods for the determination of crop protection agent residues in tobaccos and tobacco products by LC-MS/MS using the QuEChERS extraction

    DEGER A.; JACCARD G.
    Philip Morris International Management SA, Product and Process Quality, Neuchatel, Switzerland
    We will present two improved methods to determine Crop Protection Agent (CPA) residues in tobaccos and tobacco products and discuss their development and validation. The methods are applicable to 53 of the 118 CPA recommended in the CORESTA Guide No. 1 [1 ...
  5. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 02

    Development of a systems toxicology approach and its application to quantify the biological impact of tobacco smoke in vitro and in vivo

    PEITSCH M.C.; MATHIS C.; WAGNER S.; KOGEL U.; POUSSIN C.; SCHLAGE W.; STINN W.; MEURRENS K.; WEISENSEE D.; GEBEL S.; BELCASTRO V.; XIANG Y.; MARTIN F.; SEWER A.; HENGSTERMANN A.; ANSARI A.; HOENG J.
    Philip Morris International R&D, Philip Morris Products SA, Neuchâtel, Switzerland
    The potential health risks of long-term exposure to biologically active substances such as therapeutic drugs or environmental toxins are frequently determined a posteriori through clinical epidemiology studies. However, disease may take decades to ...
  6. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 28

    CSEO – The cigarette smoke exposure ontology

    YOUNESI E.(1), COGGINS C.(2); ANSARI S.(3); HOENG J.(3); PEITSCH M.(3); HOFMANN-APITIUS M.(1)
    (1) Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, Germany; (2) Carson Watts Consulting, King, NC, USA; (3) Philip Morris International R&D, Neuchâtel, Switzerland
    In the past years, significant progress has been made in the development and use of experimental settings for collection of massive and precise experimental data on tobacco exposure and the diseases induced by it. Despite the growing number of such data, ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2011, Graz, STPOST 07

    Evaluation of the diagnostic accuracy of a candidate biomarker to detect use of conventional cigarettes in users of tobacco products that do not burn tobacco

    MARTIN LEROY C.(1); LINDNER D.(2); HAZIZA C.(2); FORTE N.(2); MAGNETTE J.(2)
    (1) Clinopsis SA, Concise, Switzerland; (2) Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Objective: In clinical studies to assess alternative tobacco products that heat rather than burn tobacco, a compliance biomarker is needed to detect the additional use of conventional cigarettes. Standard biomarkers of exposure to cigarette smoke ...
  8. TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 37

    A review of the literature on the degree of "compensatory" smoking of low-delivery cigarettes

    COGGINS C.; DEMPSEY R.; ROEMER E.
    Carson Watts Consulting, King, NC, USA; Philip Morris International Management SA, Neuchâtel, Switzerland
    To review trends in measures of compensatory smoking behavior over time and by method of assessment.Introduction. An analysis of the papers published on "compensatory" smoking, observed when smokers switch to lower-yielding products from higher ...
  9. Beitr. Tabakforsch. Int./Contrib. Tob. Research, 2008, 23-1, p. 1-7., ISSN.0173-783X

    Determination of environmental tobacco smoke from a second-generation electrically heated cigarette smoking system and conventional cigarettes

    OEY J.; LAU R.W.; ROETHIG H.J.
    Philip Morris USA, Research Center, Richmond, VA, USA
    This substudy of a randomized, controlled, forced switching, open-label, parallel-group clinical study in a total of 100 healthy adult male and female smokers compared environmental tobacco smoke (ETS) produced from smoking a second generation ...
  10. Beitr. Tabakforsch. Int./Contrib. Tob. Research, 2008, 23-1, p. 8-18., ISSN.0173-783X

    A modelling approach to develop machine smoking protocols reflecting human puffing behaviour for conventional cigarettes

    URBAN H-J.; GOMME W.; SCHORP M.
    Philip Morris Intl, Philip Morris Product SA, R&D, Neuchâtel, Switzerland
    Our objective was to develop machine-smoking protocols (i.e. puff volume, puff duration and puff frequency) reflecting the distribution of human smoking behaviour as a complement to the International Standard (ISO) protocol. For this purpose, a modelling ...