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688 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 48

    The in vitro biological assessment of a novel hybrid tobacco product and comparison with a cigarette smoke

    BREHENY D.; ADAMSON J.; AZZOPARDI D.; BAXTER A.; BISHOP E.; CARR T.; CROOKS I.; HEWITT K.; JAUNKY T.; LARARD S.; LOWE F.; OKE O.; TAYLOR M.; SANTOPIETRO S.; THORNE D.; ZAINUDDIN B.; GAҪA M.; LIU C.; MURPHY J.; PROCTOR C.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Cigarette smoking is a risk factor for many diseases including cardiovascular disease, lung disease, and cancer. Recently there has been an increase in the development and consumer acceptance of novel nicotine and tobacco products including...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 49

    In vitro assessment of a novel prototype e-cigarette

    DALRYMPLE A.; JAUNKY T.; TERRY A.; BOZHILOVA S.; BAXTER A.; ADAMSON J.; HEWITT K.; TAYLOR M.; CARR T.; GAÇA M.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    E-cigarettes have rapidly increased in popularity over the last decade and there is a growing consensus that e-cigarettes hold great potential for reducing the risk associated with cigarette smoking. In this study, the responses of a novel...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 50

    Vascular endothelial oxidative stress leading to hypertension: development of an AOP using in vitro assays

    LOWE F.(2); ISMAIL R.S.(1); EL-MAHDY M.A.(1); ABDELGHANY T.M.(1); ZWEIER J.L.(1); BREHENY D.(2); PROCTOR C.(2); GAҪA M.(2)
    (1) Ohio Smoking Research Center, Columbus, OH, U.S.A.; (2) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Cigarette smoking is associated with diseases including cardiovascular disease. Key events from exposure to cigarette smoke to the development of disease related endpoints can be mapped out in the form of an adverse outcome pathway (AOP). An AOP is a...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 51

    RNA-seq-based toxicogenomics shows limited impact of e-cigarette vapour on airway cells compared with cigarette smoke when matching for nicotine delivery

    HASWELL L.; BAXTER A.; BANERJEE A.; MUSHONGANONO J.; ADAMSON J.; THORNE D.; GAҪA M.; MINET E.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    There is increasing evidence from in vitro testing that e-cigarettes cause minimal damage to cell systems: however some studies reported cytotoxicity and inflammatory responses. In this study we compared the transcriptional response of MucilAir™...
  5. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 002 (Symposium)

    The role of industry in engaging with industry to develop regulatory-approved methods for tobacco and nicotine product assessment

    PROCTOR C.J.; FEARON I.M.; MARINER D.C.; WRIGHT C.; MURPHY J.
    British American Tobacco (Investments) Limited, Southampton, UK
    Industry consensus methods for product assessment are commonplace across many industrial sectors and often form the basis of regulatory approaches. In the pharmaceutical industry for example, the foundations for the assessment of the safety, quality...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 098

    Oxidative stress and oxidative damage in human lung epithelial cells induced by total particulate matter extractions from three different tobaccos

    KANG Yu; QIAO Liangiun; HU Qiao; HUA Chenfeng; XIE Fuwei; SHANG Pingping; LI Xiang; ZHAO Junwei
    Zhengzhou Tobacco Research Institute, Zhengzhou, China
    Global sales and popularity of e-cigarettes have been growing rapidly in the past few years, but there is still a big share of conventional cigarettes and other tobacco products, which had led to the concerns about the toxicities of different tobacco...
  7. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 099

    Simultaneous determination of 22 Amadori compounds in tobacco leaves by LC-MS/MS

    WANG Xiaoyu; LIU Leiyu; WANG Sheng; QIN Yaqiong; JIA Yunzhen; CUI Huapeng; PAN Lining; XIE Fuwei; LIU Huimin
    Zhengzhou Tobacco Research Institute, Zhengzhou, China
    Amadori compounds are important aroma precursors. Therefore, rapid and corrective determination of Amadori compounds is meaningful for monitoring the quality of tobacco leaves. By the end of 2016, the publicated methods have analyzed no more than 6...
  8. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 106

    A study to examine changes in exposure to cigarette smoke chemicals when a smoker switches to using a tobacco heating product. Part I: study design

    GALE N.(1); McEWAN M.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); McAUGHEY J.(1); MURPHY J.(1); LIU C.(1); PROCTOR C.J.(1); FEARON I.M.(1); SHERWOOD N.(2); BOWEN E.(3); McDERMOTT S.(3); HOLMES E.(3)
    (1) British American Tobacco (Investments) Ltd, Southampton, UK; (2) Neil Sherwood Consulting, Commugny, Switzerland; (3) Covance, Leeds, UK
    A tobacco heating product (THP), glo™, which heats rather than combusts tobacco and produces significantly reduced machine yields of chemical toxicants compared to combustible cigarettes, was assessed in this study. Biomarker of exposure (BoE)...
  9. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 107

    A study to examine changes in exposure to cigarette smoke chemicals when a smoker switches to using a tobacco heating product. Part II: study findings

    GALE N.(1); ELDRIDGE A.(1); McEWAN M.(1); ERRINGTON G.(1); MURPHY J.(1); PROCTOR C.J.(1); FEARON I.M.(1); McDERMOTT S.(2); GLEW J.(2); HEDGE A.(2)
    (1) British American Tobacco (Investments) Ltd, Southampton, UK; (2) Covance, Leeds, U.K.
    A tobacco heating product (THP), glo™, which heats rather than combusts tobacco and produces significantly reduced machine yields of chemical toxicants compared to combustible cigarettes, was assessed in this study. Biomarker of exposure (BoE)...