Search Results

30 results

  1. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 23

    Pharmacokinetics of nicotine following single controlled use of a new type of tobacco: heated tobacco product

    GILES L.(1); YUKI D.(2); SHERWOOD N.(3); GRAFF D.W.(4); NEWLAND K.(4)
    (1) JT International SA, Ballymena, Co. Antrim, U.K.; (2) Japan Tobacco Inc., Yokohama, Kanagawa, Japan; (3) Neil Sherwood Consulting, Commugny, Switzerland; (4) Celerion, Lincoln, NE, U.S.A.
    Nicotine is one of the most characteristic compounds contained in any type of tobacco product including cigarettes. Previous studies have reported that different types of tobacco products display differences in nicotine pharmacokinetics. NHTP is a...
  2. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 20

    Evaluation of a biomarker of oxidative stress: the 8-iso prostaglandin F2α: prostaglandin F2α ratio in human plasma

    MILLER P.(1); NEWLAND K.(1); DZERK A.(1); FARMEN R.(1); TRAN C.T.(2); HAZIZA C.(2); PICAVET P.(2)
    (1) Celerion, Inc., Lincoln, NE, USA; (2) Philip Morris International, Neuchâtel, Switzerland
    F2-isoprostanes have been widely studied as biomarkers of oxidative stress for various indications, including smoking. Since both enzymatic biosynthesis and chemical lipid peroxidation can generate these biomarkers, there are various interpretations...
  3. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 23

    Reductions in biomarkers of exposure (BoE) to harmful or potentially harmful constituents (HPHCs) following partial or complete substitution of cigarettes with electronic cigarettes in adult smokers

    O’CONNELL G.(1); GRAFF D.W.(2); D’RUIZ C.(3)
    (1) Fontem Ventures B.V, Amsterdam, The Netherlands; (2) Celerion Inc, Lincoln, NE, USA; (3) Fontem Ventures B.V Greensboro, NC, USA
    Changes in fifteen urine, blood and exhaled breath BoEs of HPHCs representing classes of compounds reported by FDA to be significant contributors to smoking-associated disease risks were measured in 105 clinical-confined subjects following...
  4. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 110

    Quantitative biomonitoring of urine mutagenicity: an alternative to classical ames test

    ISLAM R.(1); ISLAM C.(2)
    (1) Celerion Inc., Lincoln, NE USA; (2) Somru BioScience Inc., Charlottetown, Canada
    For more than 30 years the Ames test has been a widely used in-vitro method for the biomonitoring of urine mutagenicity due to exposure to tobacco products. Briefly, the Ames’ test detects point mutations and frame shifts based on the reversion of...
  5. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 72

    The analysis of isotopically labeled propylene glycol in e-cigarettes

    Celerion, Lincoln, NE 68502 U.S.A. & Celerion, Zürich, Switzerland
    Measurement of the excipients in e-cigarettes has become a hot topic of discussion with the release of the new draft guidance from the United States Food and Drug Administration (FDA). However difficulties in the selective measurement of the...
  6. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 15

    A comparison of two methods for the quantification of tobacco-specific nitrosamines in human urine

    Celerion, Lincoln, Nebraska, USA
    A validated method for the determination of four tobacco-specific nitrosamines (TSNAs) – NNAL, NNN, NAT, and NAB – was compared to a method published in 2009 in the Journal of Chromatography B 877: 1185-1192, by Kavvadias, Scherer, et al. Single sets...