Cooperation Centre for Scientific Research Relative to Tobacco
Centre de Coopération pour les Recherches Scientifiques Relatives au Tabac

Measurement of the excipients in eCigarettes has become a hot topic of discussion with the release of the new draft guidance from the FDA. However, difficulties in the selective measurement of the bioavailable portion of the excipients have allowed...

Since the tobacco industry is moving into the area of regulated bioanalysis, we have noted that there is confusion surrounding the type of regulatory standards required for analytical methods to be used for testing tobacco constituents and biomarkers...

It’s a simply-stated question that requires multifaceted, serious consideration. In order to quantify unknown concentrations of analytes, clearly calibrators having known concentrations of the analytes are required. However, “known” may be illusory,...

new bioanalytical assay has been developed and validated that provides improved sensitivity, reproducibility, and selectivity for the analysis of total aromatic amines exposure. The determination of aromatic amines exposure has been identified as an...

Since the tobacco industry is moving into the area of regulated bioanalysis, we have noted that there is confusion surrounding the type of and regulatory standards required for analytical methods to be used for testing tobacco constituents and...

Since the tobacco industry is moving into the area of regulated bioanalysis we have noted that there is a lot of confusion surrounding fit for purpose bioanalytical methods. Additionally, there are many bioanalytical guidelines from different...

2-Cyanoethylmercapturic acid (CEMA), 3-hydroxypropylmercapturic acid (3-HPMA), 3-hydroxypropyl-1-methylmercapturic acid (HBMA) are urinary markers of exposure to acrolein, crotonaldehyde and acrilonitrile, respectively. These glutathione conjugates...

Since the tobacco industry is moving into the area of regulated bioanalysis we have noted that there is a lot of confusion surrounding fit-for-purpose bioanalytical methods. Additionally, there are many bioanalytical guidances from different...

The selectivity advantage of MS/MS technology alone is not always sufficient to develop the most suitable method to successfully analyze biological samples. The need for extremely low limits of quantification in bioanalysis requires strong...

Background - Biomarkers have been used extensively in clinical studies to assess toxicant exposure in smokers and non-smokers and have recently been used in the evaluation of novel tobacco products. The urinary metabolite 3-HPMA, a metabolite of the...