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386 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 62

    Overview of in vitro methods used to assess e-cigarettes based on “Toxicity Testing in 21st Century” principles

    SIMMS L.(1); STEVENSON M.(1); CZEKALA L.(1); TSCHIERSKE N.(1); WALELE T.(2)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    When the National Academies of Sciences released “Toxicity Testing in the 21st Century: A Vision and a Strategy” a new toxicological paradigm was created, focusing on the use of human cell lines and the disruption of key cellular pathways. In keeping with ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 08

    Indoor air quality and surface deposition assessment following use of an open system e-cigarette

    BAUER N.(1); TSCHIERSKE N.(1); O'CONNELL G.(2); CAHOURS X.(3)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands; (3) SEITA-Imperial Tobacco Limited, Fleury-les-Aubrais, France
    Electronic cigarette (e-cigarette) nicotine delivery devices are growing in popularity worldwide. Both regulators and public health organisations are beginning to examine potential implications that exposure to exhaled e-cigarette aerosol may have on non ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 10

    Methods for characterising morphological and structural variations of cut tobacco in cigarettes during smoking

    WANG Liang(1); YIN Donghong(1); XIE Guoyong(1); LI Bin(2); TAN Xinliang(1); DU Wen(1)
    (1) Hunan Industrial Co., Ltd of CNTC, Research and Development Center, Changsha, Hunan, P.R. China; (2) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China
    The morphological and structural variations of cut tobacco significantly influence the state of a burning cigarette and the formation of smoke constituents. A series of new methods for characterising the micro-structure of cut tobacco, planar structure of ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 12

    Study on vaporisation temperature of electronic cigarette

    CUI Huapeng; ZHAO Le; FAN Meijuan; LIU Shaofeng; CHEN Li; CAI Junlan; QIN Yaqiong; DING Xue; JIANG Zhicai
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China; (2) China Tobacco Zhejiang Industrial Co., Ltd, Hangzhou, Zhejiang, P.R. China
    The vaporisation temperature of electronic cigarettes (e-cigarettes) affects the release and migration of harmful components in e-cigarettes greatly. Therefore a method for measuring the vaporisation temperature was established based on a thermocouple to ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 13

    The comparative assessment of e-cigarettes and cigarettes on cytotoxicity and proinflammatory cytokine secretion level using an air-liquid interface system

    HUA Chenfeng; QIAO Liangjun; KANG Yu; ZHAO Junwei; QIN Yaqiong; CUI Huapeng; SHANG Pingping; LIU Huimin; LI Xiang; XIE Fuwei
    Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, Henan, P.R. China
    Electronic cigarettes (e-cigarettes), as an alternative to combustible cigarettes, have become more and more popular. In this study, the cytotoxic and proinflammatory cytokine secretion response of e-cigarette vapour (e-vapour) and traditional cigarette ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 21

    The use of in vitro human biomarkers from relevant primary cell lines, to assess the effects of increasing nicotine concentration in e-liquids

    SIMMS L.(1); STEVENSON M.(1); CZEKALA L.(1); TSCHIERSKE N.(1); BERG E.(2); WALELE T.(3)
    (1) Imperial Tobacco Ltd, Bristol, U.K.; (2) DiscoverX Corporation, Fremont, CA, U.S.A.; (3) Fontem Ventures B.V. (an Imperial Brands PLC Company), Amsterdam, The Netherlands
    As part of the ongoing stewardship of electronic cigarettes, and in line with the National Academies of Sciences “ Toxicity Testing in the 21st Century: A Vision and a Strategy ”, Fontem Ventures B.V. have investigated the utility of a series of endpoints ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 44

    Validation and comparison of the neutral red uptake assay in BALB/c 3T3 and CHO-WBL cells

    HURTADO S.B; CALLUPE J.; MARTINEZ J.L.; SOOMER-JAMES J.; GROMER K.D.; KWOK V.Y.; FARABAUGH C.S.; STANKOWSKI L.F. Jr.
    Charles River Laboratories - Skokie, Skokie, IL, U.S.A.
    The neutral red uptake (NRU) assay is used to evaluate the cytotoxicity of a variety of chemicals, cigarette smoke fractions, e-liquids, medical devices, etc. in vitro. Charles River Laboratories-Skokie previously validated the NRU assay in BALB/c 3T3 ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 46

    Validation and comparison of the in vitro micronucleus assay in TK6 and CHO-WBL cells

    WELLS M.; LORENZ M.; SOOMER-JAMES J.; KAYE S.L.; GROMER K.D.; BHATTACHARYA R.; OCO K.R.; KWOK V.Y.; FARABAUGH C.S.; STANKOWSKI L.F. Jr.
    Charles River Laboratories - Skokie, Skokie, IL, U.S.A.
    The in vitro micronucleus (MN) assay is used to evaluate the potential clastogenicity and aneugenicity of a variety of chemicals and agents in vitro. Charles River Laboratories-Skokie previously validated the in vitro MN assay in TK6 cells, according to ...