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121 results

  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 05

    Assessment of in vitro toxicities demonstrated by total particulate matter (TPM) generated from current market and research reference standard cigarettes using the Bhas-42 promotor cell transformation assay

    SHUTSKY T.(1); McRAE R.(1); SZELIGA K.(1); BRUCE S.(2); JORDAN K.(1)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, NC 27102, USA; (2) MilliporeSigma (BioReliance® Toxicology Testing Services), Rockville, MD 20850, USA
    The Bhas 42 cell transformation assay (CTA) has been used to complement standard in vitro testing of tobacco products for understanding downstream biological implications of genetic toxicological changes related to tumor promotion. Investigators have...
  2. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 06

    Analysis of (S)- and (R)-nicotine in commercial nicotine samples and e-liquids and (R)-nicotine pharmacology

    DULL G.M.(1); MOLDOVEANU S.C.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco, Winston-Salem, NC, USA
    Nicotine has been studied extensively because of its presence in tobacco products. Because of its chirality, nicotine can exist in two enantiomeric forms; however, the tobacco plant produces predominantly (S)-nicotine with only a trace of...
  3. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 07

    ENDS topography across multiple platforms in an ambulatory setting

    DULL G.M.; BAXTER-WRIGHT S.; DARNELL J.; KANOBE M.; NELSON P.; PREVETTE K.; SMITH J.
    RAI Services Co., 401 N. Main Street, Winston-Salem, NC 27102, USA
    Topography, in the context of puffing behavior, is a methodology that is used to understand how consumers use a product. The Product Use and Behavior (PUB) instrument is a research tool that can effectively measure actual Electronic Nicotine Delivery...
  4. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 16

    Abuse liability evaluation of two nicotine lozenges compared to combustible cigarettes and NRT lozenge in adult smokers

    CAMPBELL C.; JIN TAO; JONES B.; ROUND E.; SCHMIDT E.; BAXTER-WRIGHT S.
    RAI Services Company, Winston-Salem, NC 27101, USA
    To examine the abuse liability (AL) of two mint-flavored hard and soft dissolvable nicotine lozenges (NL), we conducted a two-arm, five-way crossover study in confinement with healthy smokers. Subjects participated in five daily test sessions (each...
  5. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 17

    Pharmacokinetic evaluation of e-liquid flavors in three vuse electronic nicotine delivery systems (ENDS)

    HONG Kyung Soo; DELUCA P.; JIN TAO; JONES B.; SCHMIDT E.; NELSON P.; ROUND E.
    RAI Services Company, Winston-Salem, NC 27101, USA
    The impact of flavors on ENDS product use and nicotine exposure is an important factor in product regulation. As such, we evaluated the nicotine pharmacokinetics (PK) for three ENDS products (Vuse Ciro, Vibe and Solo) across four flavor variants for...
  6. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 20

    Nrf2 response to whole smoke and aerosol of two different tobacco product types in a 3D human airway model

    KEYSER B.M.(1); LEVERETTE R.(1); HOLLINGS M.(2); ROTHWELL E.(2); WERTMAN J.(1); MORGAN(1); FIELDS W.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labcorp Early Development Laboratories, Harrogate, North Yorkshire, UK
    The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, activated in human lung cells by cigarette smoke, regulates genes involved in the antioxidative stress response. Here, we evaluated the effect of cigarette whole smoke (3R4F...
  7. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 21

    Characterization of free radicals in cigarette smoke and e-cigarette aerosols by spin-trapping EPR spectroscopy

    DAVIS M.(1); PROBERT C.C.(2); SMIRNOVA T.(2); SMIRNOV A.(2); PRASAD G.L.(3)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) North Carolina State University, Raleigh, NC, USA; (3) RAI Services Company, Winston-Salem, NC, USA
    E-cigarettes have gained popularity since their introduction in the market; however, only limited data about free radical content of e-cigarette aerosols and the nature of the radicals formed are available in the literature. The overall goal of this...
  8. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 23

    Abuse liability evaluation of portioned oral nicotine products compared to combustible cigarettes and NRT gum in adult smokers

    JONES B.; CAMPBELL L.; PREVETTE K.; ROUND E.; SCHMIDT E.; BAXTER-WRIGHT S.
    RAI Services Company, Winston-Salem, NC, USA
    This study investigated subjective measures and nicotine pharmacokinetic characteristics of portioned oral nicotine pouch product (investigational products [IPs]) use among healthy adult smokers. Results from this 5-way crossover study are reported...