Help

Search Results

152 results

  1. CROM Symposium, Online, 2023, CROM 02

    Challenges and considerations related to human abuse liability testing for tobacco products: opportunities to establish tobacco-specific methods, measures, and evaluation criteria

    VANSICKEL A.R.(1); BAXTER-WRIGHT S.(2)
    (1) Altria Client Services, Richmond, VA, USA; (2) RAI Services Company, Winston-Salem, NC, USA
    The U.S. Food and Drug Administration (FDA) recommends that tobacco product manufacturers provide information regarding the abuse liability of tobacco and nicotine-containing products to support pre-market tobacco, modified risk tobacco product and...
  2. CORESTA Congress, Online, 2022, Smoke Science/Product Technology Groups, ST 04

    Actual use study of a heated tobacco product

    PRASAD K.(1); SHETTY M.(1); HART R.(1); EVANS E.(2); CAMPBELL C.(2); MAKENA P.(2); FEEHAN M.(4); KANITSCHEIDER C.(3); LYDEN J.(4); BAXTER S.(2)
    (1) British American Tobacco, Research and Development, Southampton, U.K.; (2) RAI Services Company, Winston-Salem, NC, U.S.A.; (3) Cerner Enviza, Munich, Germany; (4) Cerner Enviza, Kansas City, MO, U.S.A.
    The introduction of new tobacco products in the United States, including those that may be lower on the risk continuum than traditional combustible cigarettes (CC), requires premarket authorization by the FDA and information on how the products will...
  3. CORESTA Congress, Online, 2022, Smoke Science/Product Technology Groups, ST 09

    Reduction in urinary and blood biomarkers of tobacco exposure in smokers switched to an electronic nicotine delivery system product

    KANOBE M.N.(1); JONES B.A.(2); BROWN B.(2); CHEN P.(1); SCHMIDT E.(1); DARNELL J.(1)
    (1) RAI Services Company, Winston-Salem, NC U.S.A.; (2) Retired employees of RAI Services Company, Winston-Salem, NC, U.S.A.
    Electronic nicotine delivery system (ENDS) products have the potential to provide nicotine to adult tobacco consumers while reducing exposure to combustion-related toxicants. This study evaluated changes in biomarker(s) of exposure (BoE) to...
  4. CORESTA Congress, Online, 2022, Smoke Science/Product Technology Groups, ST 17 (also presented at TSRC 2022)

    Distinguishing tobacco-derived nicotine from synthetic nicotine in commercial nicotine samples

    DULL G.M.(1); MOLDOVEANU S.C.(2); KILBY K.B.(2)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC, U.S.A.
    Recently, synthetic nicotine (SN) has become commercially available and can be supplied as United States Pharmacopeia (USP) grade (S)-nicotine, as a 50/50 (S)/has mixture, or as a mixture in varying ratios of (has(R) enantiomers.  While both...
  8. TSRC, Tob. Sci. Res. Conf., 2022, 75, abstr. 100

    A two-arm randomized, within-arm crossover study in confinement to assess abuse liability of glo heated tobacco products

    HONG Kyung-Soo (Jason); PREVETTE K.; CHEN P.; SCHMIT E.; BURNS S.; MAKENA P.; BAXTER-WRIGHT S.A.
    RAI Services Company, Winston-Salem, NC, USA
    FDA guidance recommends assessment of abuse liability (AL) as part of a Premarket Tobacco Product Application. Recent studies on next-generation nicotine delivery systems suggest product liking, sufficient nicotine delivery, and availability of...
  9. TSRC, Tob. Sci. Res. Conf., 2022, 75, abstr. 101

    A single arm, randomized cross over study in confinement to assess abuse liability and nicotine pharmacokinetics of Vuse Alto ends

    HONG Kyung-Soo (Jason); PREVETTE K.; GIBSON G.; KREBS H.; SCHMIDT E.; JIN Tao; AYOKU S.; KIRBY T.; MAKENA P.; BAXTER-WRIGHT S.A.
    RAI Services Company, Winston-Salem, NC, USA
    FDA guidance recommends assessment of abuse liability (AL) as compared to other tobacco products on the market as part of a Premarket Tobacco Product Application. Recent publications on electronic nicotine delivery systems (ENDS) such as Vuse Alto...