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  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 19

    Analysis and differentiation of tobacco-derived and synthetic nicotine samples

    CAMPBELL P.(1); CHEETHAM A.(2); COFFA B.(2); HILLDRUP J.(2); GILLILAND S.(1); PLUNKETT S.(1,2)
    (1) Consilium, Richmond, VA, USA ; (2) Enthalpy Analytical, Richmond, VA, USA
    There is significant regulatory and economic need to distinguish between tobacco-derived (TDN) and synthetic (SynNic) in commercial products. While products that contain TDN are regulated by FDA, those with SynNic are currently exempt from regulatory...
  2. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 22 (also presented as presentation at CORESTA SSPT2021)

    Market survey of modern oral nicotine products: determination of select HPHCs and comparison to traditional smokeless tobacco products

    MARTIN A.; JABLONSKI J.J.; CHEETHAM A.G.
    Enthalpy Analytical, Richmond, VA, USA
    In an effort to combat the risks associated with traditional tobacco products, tobacco science and product innovation has been redirected towards providing the consumer with products that may limit their potential exposure to harmful or potentially...
  3. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 40

    The synthetic nicotine loophole: regulatory issues and technical challenges

    COFFA B.G.(1); GILLILAND S.(2); BURD K.(3); SPROWL E.(4); CAMPBELL P.(2); PLUNKETT S.(1,2)
    (1) Enthalpy Analytical, LLC, Henrico, VA, USA; (2) Consilium Sciences, Richmond, VA, USA; (3) North America Nicotine, Rocklin, CA, USA; (4) Pyxus International, Morrisville, NC, USA
    A significant scientific, regulatory, and economic need exists to distinguish tobacco-derived nicotine (TDN) from synthetic nicotine (SynNic) to assess its use in commercial products. Products containing TDN are regulated by FDA; however those with...
  4. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 52

    Development of an alternative rotary-like ends collection method for in vitro toxicology testing

    SCIAN M.; KOSACHEVSKY P.; SMITH M.; MCFADDEN L.; SOVICK C.; SMITH J.; KALLAM B.; PRESS E.; PICKELL T.; PATEL N.; KUMARI A.
    Enthalpy Analytical, LLC, Henrico, VA, USA
    Testing of ENDS aerosol collected condensate in the in vitro toxicology assays is limited by OECD guidelines for the maximum allowable solvent levels that can be tested, as well as the final concentration of the condensate. The concentration of...
  5. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 56 (also presented as presentation at CORESTA SSPT2021)

    Determination of organic acids by GC-FID: on cartridge derivatization by silylating reagent (MTBSTFA)

    PENNINGTON A.
    Enthalpy Analytical, Durham, NC, USA
    Organic acids are compounds that, when used in ENDS devices and e-liquids, can alter the perception and uptake of nicotine by the consumer. Traditional means of analysis by suppressed IC (Ion Chromatography) can lead to long runtimes in excess of 70...
  6. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 61

    Resolution of micronucleus induction genotoxicity in ends: in vitro and in vivo testing

    MISRA M.(1); CARMINES E.(1); SCIAN M.(2); MCCORMICK D.(3)
    (1) Chemular Inc., Hudson, MI, USA; (2) Enthalpy Analytical, Richmond, VA, USA; (3) Illinois Institute for Technology and Research Institute, Chicago, IL, USA
    One of the regulatory toxicology assays used to assess the genotoxic potential of ENDS products is by the in vitro micronucleus (ivMN) test. The hazard assessment of aerosol generated from various E-Liquids was assessed by in vitro genotoxicity...
  7. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 65

    Dissolution testing of a novel non-tobacco long cut and pouch nicotine product

    CARMINES E.(1); FRAISSINET L.(1); MARTIN A.(2); HANSON M.(3)
    (1) Chemular Inc., Hudson, MI, USA; (2) Enthalpy Analytical, Richmond, VA, USA; (3) Black Buffalo Inc., Chicago, IL, USA
    Smokeless tobacco products contain TSNAs and other HPHCs. Black Buffalo Inc. has designed a novel smokeless product that is based on a proprietary common non-tobacco agricultural commodity. The non-tobacco leaf is cured and processed like tobacco but...
  8. CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, ST 08

    Development and validation of a routine method for the determination of carbonyl compounds in heated tobacco products (HTPs) by UPLC-MS

    JABLONSKI J.J.; MARTIN A.M.; GILLMAN I.G.
    Enthalpy Analytical, LLC, Richmond, VA, U.S.A.
    Mainstream smoke is a complex mixture containing > 4800 compounds. Within this mixture there are various carbonyls which are also present on the FDA’s abbreviated and extended harmful and potentially harmful constituents (HPHC) list, such as...