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504 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 32 (also presented at TSRC 2018)

    Characterization and certification of smokeless tobacco reference products

    SLONE S.; CANETE S.; SHELTON B.; JI H.; JACK A.M.; BUSH L.; CHAMBERS O.
    Center for Tobacco Reference Products, University of Kentucky, Lexington, KY, U.S.A.
    The constituents of raw tobacco products are naturally variable, and product design, the manufacturing process and the evolving science of tobacco analytics may increase this variability. The call for certified tobacco reference materials and their ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 55

    Determination of tobacco alkaloid enantiomers using reversed phase UPLC/MS/MS

    JI H.(1); WU W.(1); FANNIN F.(2); BUSH L.(2)
    (1) Kentucky Tobacco Research and Development Center, Lexington, KY, U.S.A.; (2) Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY, U.S.A.
    N'-Nitrosonornicotine (NNN), one of the carcinogenic tobacco-specific N'-nitrosamines (TSNAs), is on the Food and Drug Administration’s list of harmful and potentially harmful constituents (HPHCs). Nornicotine, a compound of the demethylation of ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  4. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 070 (also presented at CORESTA 2018)

    Production of very low nicotine burley tobacco: short term feasibility from an agronomy viewpoint

    JACK A.M.; FISHER C.R.
    University of Kentucky, Lexington, KY, USA
    The FDA has issued an ANPRM to obtain information for developing a product standard that would lower nicotine to non-addictive levels, and requested comments on a limit of around 0.3-0.5 mg/g. We do not believe that this limit is technically feasible on a ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 095

    Characterization of microbial communities associated with three smokeless tobacco reference products and correlation with chemical characteristics

    MOE L.; GREENHUT I.; JI Huihua
    University of Kentucky, Lexington, KY, USA
    Our first objective is to characterize microbial community composition associated with loose leaf chewing tobacco, American Snus and Swedish Snus smokeless tobacco reference products (STRP) as part of the Center for Tobacco Reference Products at the ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 111 (also presented at CORESTA 2018)

    Characterization and certification of smokeless tobacco reference products

    SLONE S.; CANETE S.; JI Huihua; JACK A.M.; BUSH L.P.; CHAMBERS O.; SHELTON B.
    University of Kentucky, Lexington, KY, USA
    The constituents of raw tobacco products are naturally variable, and product design, the manufacturing process and the evolving science of tobacco analytics may increase this variability. The call for certified tobacco reference materials and their ...