Help

Search Results

27 results

  1. CORESTA Congress, Online, 2022, Smoke Science/Product Technology Groups, ST 54

    Comparison of heated tobacco product aerosol to cigarette smoke in human bronchial epithelial tissues using high content screening

    TRELLES STICKEN E.(1); WIECZOREK R.(1); POUR S.J.(1); CHAPMAN F.(2); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH, Hamburg, Germany; (2) Imperial Brands PLC, Bristol U.K.
    Laboratory studies have shown heated tobacco product (HTP) aerosols have substantially reduced numbers and levels of harmful and potentially harmful constituents (HPHCs) relative to combustible cigarette smoke. The biological impact of these aerosols...
  2. TSRC, Tob. Sci. Res. Conf., 2022, 75, abstr. 107

    Assessing the US population health impact of introducing a new e-cigarette product to market using intentions to use data

    VERRON T.; GUO Mengran; NAHDE T.; O’CONNEL G.; CAHOURS X.
    Imperial Brands, Bristol, UK
    In the absence of epidemiological data, computational models are valuable tools for predicting the likely impact of introducing a new tobacco / nicotine product to market on population health. Using best modeling practices, we have developed and...
  3. TSRC, Tob. Sci. Res. Conf., 2022, 75, abstr. 39

    Perceptions of the relative harm of electronic cigarettes compared with combustible cigarettes in the USA: analysis of the population assessment of tobacco and health (PATH) study data, 2013-2019

    CAHOURS X.; GUO Mengran; VERRON T.; O’CONNELL G.
    Imperial Brands, Bristol, UK
    Electronic cigarettes (e-cigarettes) have been acknowledged as having the potential to be substantially less harmful than smoked tobacco by an increasing number of public health authorities. Despite this, U.S. adults remain poorly informed about the...
  4. CORESTA Meeting, Agronomy/Phytopathology, 2021, Online, AP 07

    Nematodes: first steps toward the identification of markers related to Rk2 resistance gene against M. arenaria and M. javanica

    JULIO E.(1); COTUCHEAU J.(1); VOLPATTI R.(1); TRIVILIN A.P.(2); DECORPS C.(1); ENDER M.(2); DORLHAC DE BORNE F.(1)
    (1) Imperial Brands, Leaf Research, Bergerac, France; (2) Universal Leaf Tabacos Ltda, Santa Cruz do Sul, RS, Brazil
    Plant parasitic nematodes belonging to the genus Meloidogyne are the most economically harmful nematodes worldwide with the widest host range. In the seventies, commercial tobacco cultivars with the Rk1 gene, which imparts resistance to Meloidogyne...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 04

    Risk perceptions and likelihood of use of (tobacco-free oral) nicotine pouches among current, former and never nicotine users

    STONE C.; KNIGHT-WEST O.; O’CONNELL G.; TOPE A.
    Imperial Brands PLC, Research and Development, Bristol, U.K.
    Nicotine pouches deliver nicotine to the blood via the oral mucosa; since they are not combusted and contain no tobacco leaf, they have the potential to be significantly less harmful than continued combustible cigarette smoking. There is limited data...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 05

    Assessing the impact of next generation products on population health: a population modelling approach

    PHILLIPS C.V.(1); KHAKWANI A.(2); O’CONNELL G.(2); CAHOURS X.(2); TOPE A.(2)
    (1) epiphi Consulting Group, New Hampshire, U.S.A.; (2) Imperial Brands PLC., Bristol, U.K.
    Next Generation Products (NGPs) collectively represent novel nicotine-containing products that offer potentially reduced exposure to toxicants, toxicity and health risks to adult smokers compared to continued combustible cigarette smoking. To assess...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 19

    Substantial reductions in selected harmful or potentially harmful constituents in heated tobacco aerosol, compared to 1R6F reference cigarette smoke, correlate with substantially reduced in vitro toxicological outcomes

    CHAPMAN F.(1); TRELLES STICKEN E.(2); WIECZOREK R.(2); POUR S.J.(2); DETHLOFF O.(2); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany
    Heated tobacco products (HTPs) form a category of nicotine-containing next generation products (NGPs) which show potential for tobacco harm reduction (THR). This is attributed to the absence of combustion in producing a HTP aerosol, which in turn...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 45

    Meta-analysis study to establish population level estimates of NNAL in smokers and non-smokers

    AYALA-FIERRO F.(1); VERRON T.(2); LIZHNYAK P.(3); FREELAND R.(4); FROST-PINEDA K.(4); ELAMIN A.(5); PRASAD G.L.(4); SARKAR M.(3)
    (1) Juul Labs, Inc, U.S.A.; (2) Imperial Brands, U.K.; (3) Altria Client Services, U.S.A.; (4) RAI Services Company, U.S.A.; (5) Philips Morris International, Switzerland
    The purpose of this research (a project of the CORESTA Biomarkers Sub-Group) was to establish a population level estimate for the biomarker of cigarette smoke exposure, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), to serve as a baseline...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 46

    Reductions in biomarkers of exposure to selected harmful and potentially harmful constituents following complete or partial transition to myblu™ ENDS (exclusive or dual use) compared to continued combustible cigarette smoking

    MORRIS P.(1); McDERMOTT S.(2); CHAPMAN F.(2); VERRON T.(2); CAHOURS X.(2); STEVENSON M.(2); THOMPSON J.(2); CHAUDHARY N.(2,a); O’CONNELL G.(2)
    (1) Nerudia Ltd - an Imperial Brands PLC Company, Speke, Liverpool, U.K.; (2) Imperial Brands PLC, Bristol, U.K.; (3) Broughton Nicotine Services, Earby, Lancashire, U.K.
    E-cigarettes offer an alternative, potentially reduced harm, method of nicotine delivery to adult combustible cigarette (CC) smokers, with harm reduction attributed to reduced levels of harmful or potentially harmful constituents (HPHCs) in their...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 49

    Assessment of alternative cell lines for adoption within the OECD TG 129 for cytotoxicity determination

    POUR S.J.(1); WIECZOREK R.(1); CZEKALA L.(2)
    (1) Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company, Hamburg, Germany; (2) Imperial Brands PLC, Bristol, U.K.
    Neutral red uptake assay (NRU), part of the in vitro CORESTA test “battery” is one of the most commonly used cytotoxicity assays for the evaluation tobacco and next generation products (NGPs). OECD TG 129 guideline for the NRU assay was...