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350 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2023, Cancun, AP 20

    Identification and manipulation of trichome specific controlling enhanced flavor and aroma in tobacco

    LIU Hai(1); RABARA R.C.(1,2); KUDITHIPUDI C.(2); TIMKO M.P.(1)
    (1) Department of Biology, University of Virginia, Charlottesville, VA, U.S.A.; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Glandular trichomes are epidermal outgrowths found on vascular plant species, including members of the genus Nicotiana capable of synthesizing and secreting large amounts of specialized secondary metabolites (e.g., terpenoids, flavonoids,...
  2. CORESTA Meeting, Agronomy/Phytopathology, 2023, Cancun, AP 21

    Computational-based genomic, transcriptomic, and metabolic analyses of biosynthetic gene clusters in tobacco

    RABARA R.C.(1,2); LIU Hai(1); KUDITHIPUDI C.(2); TIMKO M.P.(1)
    (1) Department of Biology, University of Virginia, Charlottesville, VA, U.S.A.; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Terpenes and terpenoids contribute to the aroma and flavor that influence consumer preferences in selecting plant-based products. Computational identification of biosynthetic gene clusters (BGCs) in plants can pave the way for future biosynthetic...
  3. CORESTA Meeting, Agronomy/Phytopathology, 2023, Cancun, AP 22

    Colchicine treated tobacco – changing biochemical composition of the leaves

    DELLA VECCHIA M.G.; ZHOU Ancheng; RABARA R.C.; QI Dong; SHEN Yanxin
    Altria Client Services LLC, Richmond, VA, U.S.A.
    Colchicine has been used in agriculture since the 1930s to induce polyploidy, or the duplication of chromosome sets, in plants. In addition to its use in inducing polyploidy, colchicine has also been studied for its potential effects on secondary...
  6. CORESTA Meeting, Agronomy/Phytopathology, 2023, Cancun, WS 04

    STP overview - accelerating positive impacts on social and environmental footprints in the tobacco industry

    IRVING B.(1); KUMLIN A.(2)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Sustainable Tobacco Program (STP), Peterson Projects S.A., Carouge, Switzerland
    Programs that incorporate environmental, social, and governance (ESG) factors are increasingly prevalent in the business world, as they are drivers of long-term value especially in industries with labor-intensive supply chains such as tobacco. The...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, CROM 00

    Science starts with measurement: essential measurement science for self-report in tobacco and nicotine product research

    McCAFFREY(1); MOREAN M.(2); AFOLALU E.(3); BLACK R.(1); SHIFFMAN S.(4); SARKAR M.(5)
    (1) Juul Labs Inc., Washington DC, U.S.A.; (2) Yale School of Medicine, New Haven, CT, U.S.A.; (3) Philip Morris Products S.A., Neuchatel, Switzerland; (4) Pinney Associates, Inc., Bethesda, MD, U.S.A.; (5) Altria Client Services LLC, Richmond, VA, U.S.A.
    Consumer reported outcome measures (CROM) are a critical component of tobacco regulatory science. Examples of CROM include measures of tobacco product dependence and risk perceptions. Like other fields of science, behavioral researchers require...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, IG 01; CORESTA Meeting, Agronomy/Phytopathology, 2023, Cancun, IG 01 (also presented at TSRC 2023)

    CORESTA Tobacco Harm Reduction Workshop Overview

    STEVENS R.(1); FLORA J.(2)
    (1) RAI Services Company, Winston Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.
    In June 2022, CORESTA held a Science Day in Paris, France. Presenters included experts in tobacco harm reduction (THR); Karl Fagerström, Riccardo Polosa, Clive Bates, Luca Rossi, and Lea Scott. Topics covered included the role of nicotine in harm...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, NAM 00

    New Approach Methods (NAMs) Symposium-II: Applications in Tobacco Regulatory Sciences

    LEE K.M.(1); SIMMS L.(2)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Imperial Brands PLC, Bristol, U.K.
    New Approach Methods (NAMs) in toxicology refer generally to in vitro and in silico or computational methodologies that, without additional in vivo animal testing, could enable clinically relevant toxicological risk assessment. At CORESTA...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, NAM 02

    Connecting exposure, dosimetry and toxicity responses in the preclinical evaluation of ingredients: case examples of flavoring chemicals in oral tobacco products

    ZHANG Jingjie
    Altria Client Services LLC, Richmond, VA, U.S.A.
    Flavoring ingredients that are GRAS (“generally recognized as safe”) in food are commonly used in oral tobacco derived nicotine (OTDN) products. While the GRAS status is not de facto approval for the use in oral tobacco products, the accompanying...