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1595 results

  1. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 05

    Assessment of in vitro toxicities demonstrated by total particulate matter (TPM) generated from current market and research reference standard cigarettes using the Bhas-42 promotor cell transformation assay

    SHUTSKY T.(1); McRAE R.(1); SZELIGA K.(1); BRUCE S.(2); JORDAN K.(1)
    (1) Scientific & Regulatory Affairs, RAI Services Company, Winston-Salem, NC 27102, USA; (2) MilliporeSigma (BioReliance® Toxicology Testing Services), Rockville, MD 20850, USA
    The Bhas 42 cell transformation assay (CTA) has been used to complement standard in vitro testing of tobacco products for understanding downstream biological implications of genetic toxicological changes related to tumor promotion. Investigators have...
  2. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 06

    Analysis of (S)- and (R)-nicotine in commercial nicotine samples and e-liquids and (R)-nicotine pharmacology

    DULL G.M.(1); MOLDOVEANU S.C.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) R.J. Reynolds Tobacco, Winston-Salem, NC, USA
    Nicotine has been studied extensively because of its presence in tobacco products. Because of its chirality, nicotine can exist in two enantiomeric forms; however, the tobacco plant produces predominantly (S)-nicotine with only a trace of...
  3. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 07

    ENDS topography across multiple platforms in an ambulatory setting

    DULL G.M.; BAXTER-WRIGHT S.; DARNELL J.; KANOBE M.; NELSON P.; PREVETTE K.; SMITH J.
    RAI Services Co., 401 N. Main Street, Winston-Salem, NC 27102, USA
    Topography, in the context of puffing behavior, is a methodology that is used to understand how consumers use a product. The Product Use and Behavior (PUB) instrument is a research tool that can effectively measure actual Electronic Nicotine Delivery...
  4. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 08

    Trapping efficiency study of fine particulate aerosols in the pocket and phlip commercial personal handheld filtration devices

    GRIMM J.(1); WRIGHT D.(2); WERLEY M.S.(3); MCKINNEY W.J.(4)
    (1) Philter Labs Inc., El Cajon, CA, USA; (2) IBR Laboratories, Grass Lake, MI, USA; (3) Fairview Consulting, Fredericksburg, VA, USA; (4) McKinney Regulatory Science Advisors, Henrico, VA, USA
    Personal handheld filtration devices used in combination with conventional electronic nicotine delivery systems (ENDS) provide a convenient, and effective means to significantly lower environmental and bystander exposure to exhaled vapor. A growing...
  5. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 11 (also presented as presentation at CORESTA SSPT2021)

    Biomarkers of potential harm in smoking abstinence and in the use of Vuse electronic nicotine delivery systems (ENDS)

    MAKENA P.
    RAI Services Company, Winston-Salem, NC, USA
    Qualified Biomarkers of Potential Harm (BoPH) are useful in evaluating the beneficial effects of abstinence from cigarette smoking or switching to potentially reduced risk tobacco products. We benchmarked BoPH changes in a 14-Day smoking abstinence...
  6. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 12

    Analysis of counterfeit e-liquids using flavoring profiles by gas chromatography with mass spectral detection

    LORENZ L.M.; GRIFFIN K.M.; PARSONS M.
    U.S. Food and Drug Administration, Office of Regulatory Affairs, Office of Regulatory Science, Office of Medical Products and Specialty Laboratory Operations, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA
    In August 2016, the Food and Drug Administration finalized a rule extending FDA’s authority to regulate tobacco products to include, among other things, electronic nicotine delivery systems (ENDS). To support investigations of counterfeit ENDS...
  7. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 13

    A 12 month stability study on JUUL Virginia tobacco flavored aerosols using a two non-targeted analytical methods

    CROSSWHITE M.R.; JEONG L.N.; JAMESON B.; LIOUBOMIROV A.; YANGA C.; OZVALD A.; GILLMAN G.
    JUUL Labs, Washington, DC, USA
    Combustible cigarette (CC) smoking is the leading cause of preventable human death. The United States Food and Drug Administration (FDA) Family Smoking Prevention and Tobacco Control Act, protects public health by regulating the manufacturing,...
  8. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 14

    Extractables testing plan for an improved data collection needed for effective risk assessment in electronic nicotine delivery systems

    CHEVVA H.; AYALA-FIERRO F.; HIRAKI B.; FORD K.; COOK D.
    JUUL Labs, San Francisco, CA, USA
    Extractables & Leachables (E&L) studies evaluate the likelihood of product contacting-materials to leach unwanted substances into consumer products including pharmaceuticals, food, medical devices and electronic nicotine delivery systems...