Cooperation Centre for Scientific Research Relative to Tobacco
Centre de Coopération pour les Recherches Scientifiques Relatives au Tabac

The Electronic Nose (E-Nose) response has been optimized by an experimental design aimed at defining a standard method to analyze blend tobacco. A possible application of this apparatus is to use it as an "on line" quality control tool in...

Near infrared reflectance spectroscopy has proved to be very useful for predicting concentrations of chemical compounds in tobacco, classification or pattern recognition of cigarette blends. The resulting measurement of a sample is a whole...

The ISO or FTC smoking conditions (35 mL - 2 s puffs, 1 puff per minute) have been more and more criticized during the last decade, especially because they would not reflect the human smoking behaviour. Their main objective was not to predict the...

The objective of this paper is to examine the effects of six tobacco components on the chemical and physical characteristics of blends and cigarettes and particularly on the mainstream smoke yields. First of all, we will develop the philosophy of...

Today in the tobacco industry, one of the main scientific challenges is to understand the formation of some smoke compounds ("Hoffmann analytes"). For several years, work has been conducted in order to know the influence of cigarette design...

In order to mimic the aromatic modifications occurring in tobaccos during combustion, a preparation method, applied on tobacco samples, is carried out. Tobacco samples are heated under pressure at 170 °C during 2 hours. In such conditions, Maillard...

An automated puff-by-puff mainstream smoke system is developed to monitor real time gas phase in mainstream cigarette smoke. Simple and sensitive, the real-time analysis delivers, without pre-treatments, a rapid fingerprint of the volatile profile as...

The aim of this work was to develop an in vitro model for direct exposure of human lung cells (A549) to native cigarette whole smoke, in a specially adapted exposure module based on the CULTEXTM cell cultivation system. Our system consists in three...

As Hoffmann list component, hydrogen cyanide is currently analyzed. Design and filter parameters are involved on HCN amount in smoke, however tobacco composition explains strongly the quantitative results. The known relations between HCN and nitrogen...

In order to increase our efficiency in assessing the cigarette smoke's toxicity, we developed fast cell-free methods allowing a first selection before in vitro classical testings. We will here describe a cell-free method, based on the depletion of...