Cooperation Centre for Scientific Research Relative to Tobacco
Centre de Coopération pour les Recherches Scientifiques Relatives au Tabac

An automated puff-by-puff mainstream smoke system is developed to monitor real time gas phase in mainstream cigarette smoke. Simple and sensitive, the real-time analysis delivers, without pre-treatments, a rapid fingerprint of the volatile profile as...

The aim of this work was to develop an in vitro model for direct exposure of human lung cells (A549) to native cigarette whole smoke, in a specially adapted exposure module based on the CULTEXTM cell cultivation system. Our system consists in three...

Draw resistance is felt by the consumer when his cigarette is lit, not before. In spite of this obvious fact, this physical parameter is usually measured on unlit cigarette. In order to assess more accurately the smoker's feeling, the theoretical...

We published last year results indicating that under natural conditions, the total smoke exposure decreased for smokers switching from a full flavour brand to the light corresponding brand. The amount of the decrease was then concordant with the...

Chemical analyses of special analytes (e.g. TSNAs) or biological tests on the smoke are rather sophisticated and time consuming technologies. Giving estimates based on fast analyses would enable the blenders to have a tool allowing them to reduce...

Cigarette smoke (CS) contains numerous compounds, among which free radicals and aldehydes that can potentially react with low molecular antioxidants, such as glutathione (GSH). Thus, the GSH depletion measurement can be used to assess the oxidative...

Group classification of tobacco blends is commonly performed using several different types of compositional data including tobacco compounds, additive or process components. But all of these wet chemistry methods are relatively time-consuming. A need...

Initiatives for developing and using alternative tests in toxicology for regulatory purposes can be traced back to the 1970's. In the last 30 years various in vitro methods have been developed to replace and to limit the use of laboratory animals....

The behavior of a cigarette, during a puff, is strongly determined by the air flow distribution inside. In order to better understand this behavior, a theoretical model has been used which is able to predict the pressure drop as well as the paper and...

The objectives of this study were to investigate the mechanisms of transfer of ammonia in smoke from the ammonium compounds in tobacco and the consequences of this transfer for other smoke constituents (in particular nicotine). A survey of 54...