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  1. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, NAM 00

    Advancing new alternative methods for tobacco harm reduction

    LEE K.M.(1); BELL S.(2)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Integrated Laboratory Systems (ILS), Morrisville, NC, U.S.A.
    New approach methodologies (NAMs) represent in vitro and in silico or computational methodologies, an emerging set of chemical safety assessment tools without needing additional in vivo animal testing. This virtual Symposium introduced the current...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, NAM 01

    US federal efforts to develop and implement alternatives to animal testing

    KLEINSTREUER N.
    NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), U.S.A.
    The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) is made up of representatives from US federal agencies that require or consider chemical safety testing data, and are interested in more rapid, human-relevant...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, NAM 02

    Application of biokinetic modelling for in vitro to in vivo extrapolation (IVIVE) in chemical risk assessment

    PAINI A.(1); WORTH A.(2)
    (1) esqLABs GmbH, Saterland, Germany; (2) European Commission Joint Research Centre (JRC), Ispra, Italy
    In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses,...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, NAM 06

    Application of mechanistic data in risk assessment: exposure alignment and evidence integration

    JARABEK A.M.
    U.S. Environmental Protection Agency’s Office of Research and Development (ORD), U.S.A.
    Risk assessment relies on integration of evidence across several data streams by necessity. Conceptual constructs for source-to-outcome modeling based on aggregate exposure pathway (AEP) and adverse outcome pathway (AOP) frameworks can provide a...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 01

    Development of consumer-reported outcome measure (CROM) standards for the tobacco industry with respect to psychometric CROM using a consortium-based approach: methodology and scope

    McCAFFREY S.(1) on behalf of the CORESTA CROM Task Force (WG02): AFOLALU E.(2); BLACK R.(1); CHREA C.(2); CURTIN G.(3); GILES L.(4); NISHIHARA D.(4); PRASAD K.(5); SARKAR M.(6); SHETTY M.(5)
    (1) JUUL Labs, Inc., San Francisco, CA, U.S.A.; (2) Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) JT International S.A., Geneva, Switzerland; (5) British American Tobacco, Southampton, U.K.; (6) Altria Client Services, Richmond, VA, U.S.A.
    In November 2018, CORESTA approved the formation of a new Task Force (TF) to establish best practices and guidelines for the integration of consumer-reported outcome measures (CROM) in tobacco regulatory research. The primary objective of the CROM TF...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 02

    Descriptive consumer reported outcome measures and definitions in tobacco and nicotine research: a consensus approach

    WEI L.(1) on behalf of the CROM Task Force: CLERC E.(2); SHETTY M.(3); CHREA C.(2); PRASAD K.(3); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, Virginia, U.S.A.; (2) Philip Morris International, Neuchâtel, Switzerland; (3) British American Tobacco, Southampton, U.K.
    The Consumer Reported Outcome Measures (CROM) Consortium Task Force (TF), consisting of academic researchers and members from various tobacco companies, was formed within the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) in...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 03

    Psychometric validation of new scales expanding conceptual coverage of the ABOUT-Perceived Risk: perceived social risk and perceived practical risk

    CLERC E.(1); SALZBERGER T.(2); CANO S.(3); AFOLALU E.(1); CHREA C.(1)
    (1) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Institute for Statistics and Mathematics, University of Economics and Business, Vienna, Austria; (3) Modus Outcomes, Letchworth Garden City, U.K.
    The ABOUT™—Perceived Risk is a self-report instrument, developed by Philip Morris Products SA, designed to assess perceived risks associated with the use of a wide range of tobacco and/or nicotine containing products (TNP), such as cigarettes,...