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995 results

  1. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 075

    Analysis of nicotine, menthol, water, propylene glycol, and glycerin in tobacco heated product

    LANDINGHAM T.; SIERNOS M.; POSTEN C.; ALMOND C.; MICKEY D.D.; ADAMS C.J.; CHOUCHANE S.
    Eurofins Professional Scientific Services, Winston-Salem, NC, USA
    As the Tobacco Heated Product (THP) industry is expanding, the accurate analysis of nicotine, water, menthol, glycerin, and propylene glycol has become increasingly important with regard to regulatory submissions. To evaluate these products, an...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 076

    Nicotine in vivo extraction and pharmacokinetics of non-tobacco-based nicotine pouches (ZYN®) compared with tobacco-based swedish snus and american moist snuff

    STAAF M.; LJUNG T.; PENDRILL R.
    Swedish Match, Stockholm, Sweden
    Objectives • To compare in vivo extracted dose and pharmacokinetics of nicotine from ZYN® with Swedish snus (General) and U.S moist snuff (Longhorn) • To evaluate the effect of the flavor component methyl salicylate on nicotine extraction and uptake...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 077 (also presented at CORESTA SSPT2019)

    Comparison of methods for measuring the particle size distribution of smokeless tobacco products

    PLATT S.P.; JACKSON C.; DILL K.; RUSYNIAK M.
    Altria Client Services, Richmond, VA, USA
    Tobacco cut size is one of the product properties for smokeless tobacco products, which the Food and Drug Administration has proposed as a requirement for a Substantial Equivalence (SE) submission. (21 CFR Parts 16 and 1107). However, no guidance has...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 078

    Probabilistic risk assessment to compare health risks of oral tobacco products

    SANTAMARIA A.B.(1); KROTENBERG M.E.(2); DROUIN S.M.(1); EHMAN K.D.(3); ANDERSON C.A.(3); HAASE V.(3); SMITH D.C.(3)
    (1) Rimkus Consulting Group, Houston, TX, USA; (2) Rimkus Consulting Group, Phoenix, AZ, USA; (3) Altria Client Services, Richmond, VA, USA
    In the evaluation of substantial equivalence (SE) for tobacco products for submission to the US Food and Drug Administration (FDA), differences in harmful and potentially harmful constituents (HPHCs) may necessitate the determination of whether a new...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 079

    Comparison of the acetaldehyde, formaldehyde, and acrolein yields in cigars under different smoking regimens using a linear cigarette smoking machine

    YOUNG M.; CECIL T.L.; JOHNSON T.; FENG S.
    US Food and Drug Administration (FDA), Calverton, MD, USA
    Currently, there is very little information on the mainstream smoke yields of carbonyl compounds (e.g., formaldehyde, acetaldehyde, and acrolein) in cigar tobacco products. This study used a standard linear smoking machine and puffing protocols to...