1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 41

    Human chemical signature – investigation on the influence of human presence and selected activities on concentrations of airborne constituents

    MITOVA M.I.; GOUJON-GINGLINGER C.; ROTACH M.; MAEDER S.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Available indoor air quality (IAQ) studies on tobacco- and nicotine-containing potentially reduced-risk products (PRRPs), such as electrically heated tobacco products and e-cigarettes, demonstrate substantial reduction of environmental emissions compared ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 42

    Study on aerosol deposition in the respiratory tract of consumers using cigarette, electronic cigarette or heat-not-burn product

    CUI Huapeng(1); LI Yawen(1); FAN Meijuan(1); CHEN Li(1); SI Xiaoxi(2); HAN Jingmei(2); CAI Junlan(1); LI Xiang(1); LIU Shaofeng(1); XIE Fuwei(1); XIE Jianping(1)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, P.R. China; (2) R&D Center, China Tobacco Yunnan Industrial Co., Ltd., Kunming, P.R. China
    The deposition of aerosols inhaled into the human respiratory tract is key to evaluate exposure and risk during product use. A method based on a differential mobility spectrometer (DMS) was established for determining the physical properties of smoke ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the available ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs). The ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 46

    Analysis of aroma components in oral fluids of cigarette smokers

    FEI Ting; BI Yanjiu; LIANG Demin; QI Dawei; TAO Liqi; YU Jie; WU Da; LIU Baizhan
    Technology Center, Shanghai Tobacco Group Co., Ltd., Shanghai, P.R. China
    The sensory quality of cigarettes depends on the effects of chemical components in the mainstream smoke on the consumer’s sensory organs. To provide a reference for cigarette quality assessment, a method for analysing aroma components in the oral fluids ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 47

    A high-throughput and sensitive bioanalytical method for quantification of nicotine and cotinine in rat/mouse plasma using reversed-phase liquid chromatography–tandem mass spectrometry and its application in inhalation study sample analysis

    SAXENA A.(1); ZHANG Chunyan(1); CIPUTRA T.(1); CHNG Yun Xuan(1); PHILLIPS B.(1); VANSCHEEUWIJCK P.(2)
    (1) PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Singapore; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    Nicotine and cotinine are used as primary biomarkers to estimate the exposure of reduced-risk products, such as e-liquids/heated tobacco products, in comparison with cigarettes. The objective of this study was to develop and validate a method per current ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 48

    Analysis of four volatile nitroso-amines, four alkaloids, 18 polycyclic aromatic hydrocarbons in oral tobacco products based on simultaneous extraction technique and GC-MS/MS detection

    WANG Xiaoyu(1); QIN Yaqiong(1); XIE Fuwei(1); LI Dongliang(2); SHEN Yi(2); GUO Junwei(1); LIU Shaofeng(1); LUO Cheng(2); PAN Lining(1); WANG Sheng(1)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, P.R. China; (2) Technology Center, China Tobacco Sichuan Industrial Co., Ltd., Chengdu, P.R. China
    Many kinds of harmful or potentially harmful components (HPHCs) exist in oral tobacco products. Usually, each kind of chemical needs a specific analytical method, which will cause high cost and low throughput. Therefore, the objective of this study was to ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 49

    Automation of analytical procedures for mycotoxins, acrylamide, aldehydes and NDMA using Tecan Fluent 1080 automation workstation system

    AVAGYAN R.; BRUNO O.; PATRING J.; LINDHOLM J.
    Swedish Match North Europe AB Europe Division, Stockholm, Sweden
    Mycotoxins, acrylamide, aldehydes and N-nitrosodimethylamine (NDMA) are constituents included on the FDA "Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke: Established List" and considered as large volume ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 50 (also presented at TSRC 2019)

    In vitro dissolution testing of nicotine release from smokeless tobacco products

    MILLER J.H.; DANIELSON T.L.; ALDEEK F.; PITHAWALLA Y.B.; WILKINSON C.T.; BROWN A.P.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Developing dissolution testing methods to measure the nicotine release profiles from smokeless tobacco products is valuable for product assessment and for product-to-product comparisons. Furthermore, it can allow for understanding which physical or ...