Study on nicotine release from snus products with fiber-optic sensing detection technology
In order to strengthen the quality and safety control of snus products, the development and application of an optical fiber sensing drug dissolution analyzer were investigated to study nicotine release. An automatic testing method for the in situ release of nicotine from pouched snus was developed to evaluate the dynamic of nicotine release, and samples of four commercial products were characterised. Samples were placed in the settlement basket of a modified YR-1A optical fiber nicotine dissolution meter and then were analyzed following the operating process, finally the nicotine dissolution diagram was obtained and the level of nicotine release rate (min-1), ʎ, was calculated. Experimental results showed that after 45 minutes, the nicotine dissolution from samples became stable. The nicotine concentration/response relationship curve was linear within 10-80 µg/ml and the correlation coefficient was 0.999. The coefficients of variation of nicotine release ranged from 3.4 % to 7.4 %. Approximately 62 %-94 % of nicotine in the samples was released, and the range of ʎ was between 0.02 min-1 and 0.06 min-1. The design of the instrument integrated optical fiber technology, spectrum technology, computer technology and analysis technology as a whole. The input spectral signal of nicotine concentration was processed by computer automatically, and the sampling frequency and measurement time were accurately controlled at the second level. The designed optical fiber nicotine dissolution meter allows the in situ continuous, real-time and on-line analysis of nicotine release from snus products.