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TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 32

Subjective effects associated with relx infinity electronic nicotine delivery system (ENDS) use in an 8-week switching study of adult smokers

GRAFF D.(1); XIE Yuli(2); CIRIC S.(2)
(1) Cheerain HK Limited, Hong Kong, China; (2) Celerion Inc., Lincoln, Nebraska, USA

Changes in a panel of subjective effects questionnaires in cohorts of smokers who switched from combustible cigarettes to the RELX Infinity ENDS were evaluated in an 8-week, randomized, parallel-cohort study of adult smokers.

Subjects smoked their own-brand cigarettes through the baseline visit and were randomized to receive a RELX Infinity ENDS with a tobacco or menthol flavored e-liquid based on their own-brand combustible cigarette flavor, both e-liquid flavors, or to continue smoking. Subjects returned to the clinic every 2 weeks to complete questionnaires, including the Questionnaire of Smoking Urges-Brief (QSU), Penn State (Electronic) Cigarette Dependence Index (PS(E)CDI), Minnesota Tobacco Withdrawal Scale-Revised (MTWS-R), modified Product Evaluation Scale (mPES), and Future Intent to Use Questionnaire (FIU), along with other endpoint assessments.

A total of 194 subjects were randomized and 170 subjects completed the study, including 150 who switched to the RELX Infinity ENDS. Compared to baseline, all cohorts switching to the RELX Infinity ENDS experienced significant decreases in QSU factor scores and MTWS-R and PSECDI total scores by Week 2, with scores continuing to be lower than baseline through Week 8. mPES Satisfaction, Psychological Reward, and Relief subscale responses tended to be higher at baseline compared to post-baseline, although directional and statistically significant differences varied across time points and cohorts. Intent to purchase the RELX ENDS tended to increase slightly over time along with a lower intent to smoke following the study compared to intent at baseline.

These data support the potential for the RELX Infinity ENDS to provide a substitute for cigarettes, including the ability to reduce withdrawal symptoms and urges to smoke, produce satisfaction and relief, and generate reinforcing effects which would stimulate continued use by smokers.