Different approaches have been reported in the literature to reduce the TSNA levels in mainstream smoke (MS). The reduction of TSNA in the raw tobacco is an approach that has received a lot of attention in recent years. Different elements determine the level of TSNA in MS smoke. During combustion, part of the TSNA in the cigarette filler can transfer into smoke while another portion can undergo thermal degradation. Moreover, it is possible that TSNA can be pyrosynthesized and that concomitant synergetic effects between the blend components can also occur. Depending on their extent, the formation and degradation of nitrosamines during the combustion process might have an important impact on TSNA level in the smoke of blended cigarettes and might lead to MS TSNA deliveries which would not parallel that of the blend constituents. A study was therefore undertaken to assess the feasibility of predicting the TSNA deliveries of blended products on the basis of the TSNA deliveries of the individual blend constituents. A highly simplified blend-model was chosen, including Virginia, burley and oriental tobacco in fixed proportions. A set of one-, two- and three-component prototypes was prepared with various combinations of high- and low-TSNA Virginia and burley tobacco. The pre-formed TSNA levels of the different blend constituents and the MS deliveries of the prototypes were determined. The TSNA deliveries of the blended prototypes were found to be in good agreement with the predictions based on both the MS TSNA delivery and the pre-formed TSNA content of the individual blend constituents. The study showed that predicting MS TSNA levels in the smoke of blended cigarettes could probably be achieved with adequate accuracy from the levels measured in the smoke of the laminar blend constituents. Strong indications were obtained that such predictions could be made from the pre-formed TSNA content of the raw tobacco. With respect to the reduction of TSNA in MS smoke, the reported results provided evidence that procuring tobaccos with very low levels of pre-formed TSNA would be an effective strategy to reduce the content of TSNA in MS smoke.