Some regulators only want data on a product's emissions and/or certain constituents in the tobacco or e liquids (e.g. U.S. FDA harmful and potentially harmful constituents [HPHC]). Other regulators want information on new constituents formed during processing (e.g. possible reaction of reducing sugars with amino acids and proteins in the tobacco) or storage/shipment (e.g. possible formation of acetals in an e liquid containing aromatic aldehydes and propylene glycol). Regulators have also called for data to show that products have been manufactured correctly. Numerous techniques and methods have been reported in the literature, conference proceedings, and legacy documents that can be used to provide data to the regulators. However, many of the techniques and methods require complex instrumentation and highly-trained laboratory personnel such as found at the major tobacco and e vapor companies and commercial laboratories. Consequently, something simpler is needed. One approach is liquid chromatography (e.g. LC, HPLC), but not with the column technology used in the past (e.g. methods for casings on tobacco). The new technology involved the so-called Type C silica and permits the columns to be used in both the traditional reverse-phase (RP) and new aqueous-mobile-phase (ANP) modes. Thus, samples of e liquids or tobaccos, diluted with or extracted with 50/50 (v/v) acetonitrile/water, can be chromatographed under normal RP conditions and alternate separations to resolve coeluting peaks performed under ANP conditions. This can be done without changing columns. Examples will be provided using a Cogent Phenyl Hydride column and a YMC Triart C18 column with gradients of water-acetonitrile for RP separations and acetonitrile-water for ANP separations. Examples will be provided for complex e liquids, heavily processed commercial tobacco products (e.g. pipe tobaccos) and artificial salivas exposed to e cigarette aerosols.