No. 74 - Determination of Selected Carbonyls in Mainstream Cigarette Smoke by High Performance Liquid Chromatography (HPLC)
(CRM developed into ISO 21160; ISO 23922)
This Recommended Method is applicable to the determination of selected carbonyls (formaldehyde, acetaldehyde, acetone, acrolein, propionaldehyde, crotonaldehyde, 2-butanone and n-butyraldehyde) as their 2,4-dinitrophenylhydrazones in mainstream smoke from cigarettes with ISO NFDPM yields between 1 mg/cigarette and 15 mg/cigarette using reversed phase HPLC-UV/DAD.
The described method is specified using ISO 3308 and ISO 20778 (Intense) smoking parameters. The use of these machine smoking parameters reflects their inclusion in the reporting requirements of various national regulations rather than an endorsement of their appropriateness by CORESTA.
Report - 2012 Collaborative Study on B[a]P, VOCs, and Carbonyls in Mainstream Cigarette Smoke (August 2019)
Report - Updates of CORESTA Recommended Methods after Further Collaborative Studies Carried Out under Both ISO and Health Canada Intense Smoking Regimes (December 2013)
Report - Determination of Carbonyl Compounds in Cigarette Mainstream Smoke. The CORESTA 2010 Collaborative Study and Recommended Method (June 2012)