Recommended Methods current

No. 63 - Determination of Tobacco Specific Nitrosamines in Cigarette Mainstream Smoke - GC-TEA Method

(CRM developed into ISO 22303; ISO 22304)

January 2019 - second edition Ref. SMA-163-CRM-63

This Recommended Method is applicable to the determination of four Tobacco Specific Nitrosamines (TSNAs) in the total particulate matter of cigarette mainstream smoke.  The determined TSNAs are: N-Nitrosonornicotine (NNN), N-Nitrosoanabasine (NAB), N‑Nitrosoanatabine (NAT) and 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK).

The described method is specified using ISO 3308 smoking parameters, but is technically compatible with other smoking regimes.


Related documents

CRM 75 - Determination of Tobacco Specific Nitrosamines in Mainstream Cigarette Smoke by LC-MS/MS (August 2019)

CRM 23 - Determination of Total and Nicotine-Free Dry Particulate Matter using a Routine Analytical Cigarette - Smoking Machine Determination of Total Particulate Matter and Preparation for Water and Nicotine Measurements (Aug. 1991)

CRM 22 - Routine Analytical Cigarette-Smoking Machine: Specifications, Definitions and Standard Conditions (Aug. 1991)

CRM 21 - Atmosphere for Conditioning and Testing Tobacco and Tobacco Products (Aug. 1991)

Report - Updates of CORESTA Recommended Methods after Further Collaborative Studies Carried Out under Both ISO and Health Canada Intense Smoking Regimes (December 2013)

Report - Determination of Tobacco Specific Nitrosamines in Cigarette Mainstream Smoke. The CORESTA 2011 Collaborative Study (December 2012)