Recommended Methods current

No. 72 - Determination of Tobacco-Specific Nitrosamines in Tobacco and Tobacco Products by LC-MS/MS

(CRM developed into ISO 21766)

December 2021 - fifth edition Ref. TTPA-284-2-CRM-72

This Recommended Method is applicable for the determination of TSNAs in tobacco and tobacco products. Supporting repeatability and reproducibility data are included for ground tobacco, cigarette filler, cigar filler, smokeless tobacco products (e.g. moist snuff, snus, chewing tobacco and dry snuff) and nicotine pouches. The TSNAs determined with this method are: N-nitrosonornicotine (NNN), 4-(N-methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosoanatabine (NAT), and N-nitrosoanabasine (NAB).


Related documents

CRM 102 - Determination of Tobacco-Specific Nitrosamines in E-Liquid by LC-MS/MS (January 2023)

CRM 76 - Determination of Moisture Content (Oven Volatiles) of Tobacco and Tobacco Products (December 2021)

Report - 2021 Nicotine Pouches Collaborative Study (October 2021)

Report - 2017 Collaborative Study on TSNA, pH, and Moisture (Oven Volatiles) (July 2017)

Report - CORESTA Reference Products (Smokeless Tobacco) - 2015 Analysis (December 2015)

Report - CORESTA Smokeless Tobacco Sub-Group - Working Group 2 - 2009 Collaborative Study Report (July 2010 - updated Jan 2016)

Guide 11 - Technical Guideline for Sample Handling of Smokeless Tobacco and Smokeless Tobacco Products (May 2020)