Select Carbonyls in Tobacco and Tobacco Products - 2016/2017 Collaborative Study
TTPA Technical Document
The objective of this study was to evaluate the method developed within the Smokeless Tobacco Sub-Group (STS) (now named Tobacco and Tobacco Products Analytes Sub-Group, TTPA) for the determination of carbonyls in tobacco products including smokeless tobacco products and cigarette filler. The data were statistically evaluated in basic conformance with the recommendations of ISO 5725-2 to assess within (r) and between laboratory (R) variability. The study suggested the method is sufficiently robust for the determination of carbonyls in tobacco products and a CORESTA Recommended Method (CRM 86) was subsequently drafted and published.
In addition to this study, the stability of carbonyl concentrations were investigated to determine if they are affected by transportation, grinding, and refrigerated storage after weighing out aliquots. However, the tests were limited robustness tests from which no certain conclusions could be drawn.
CRM 86 - Determination of Select Carbonyls in Tobacco and Tobacco Products by UHPLC-MS/MS (January 2018)