CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPTPOST 19
The in vitro micronucleus assay for cigarette smoke condensate samples: Photomicrographs for micronucleus scoring and analysis of historical data obtained from Kentucky reference cigarette 3R4F
SAWAGURI J.(1); HORI K.(2); SAKIMURA M.(3); SOFUNI T.(1)
(1) Japan Tobacco Inc., Scientific and Regulatory Affairs Division, Tokyo, Japan; (2) Mitsubishi Chemical Medience Corp., Drug Development Service Segment, Ibaraki, Japan; (3) Japan Tobacco Inc., Product Science Division, Yokohama, Kanagawa, Japan
The in vitro micronucleus (MNvit) assay is a genotoxicity test that was developed as an alternative to the chromosomal aberration assay with the advantage of detecting both structural aberrations and numerical aberrations (aneuploidy). We conducted...