TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 045
Highly sensitive nicotine plasma and metabolite assays for clinical trials by LC-MS/MS
KCAS Bioanalytical and Biomarker Services, Shawnee, KS, USA
Human plasma assays for nicotine and its key metabolites (cotinine and trans-3’-hydroxycotinine) have been validated in compliance with FDA guidelines in support of clinical trials. Success in establishing these assays is careful screening of all...