CORESTA Congress, Online, 2020, Smoke Science/Product Technology Groups, STPOST 14
Mode-of-action analysis of the induction of micronuclei by a flavouring compound in vitro
WATANABE T.; MUNAKATA S.; ISHII T.; SAITO J.; ERAMI K.; HASHIZUME T.
Japan Tobacco Inc., R&D Group, Scientific Product Assessment Center, Yokohama, Kanagawa, Japan
A compound showing a positive result on the in vitro micronucleus test (MNT), one of the standard battery of genotoxicity tests, must be followed-up with in vivo MNT. However, not uncommonly, some in vivo MNT results are negative, indicating...