CORESTA Meeting, Smoke Science/Product Technology, Jeju, 2007, SSPTPOST 15
A ring trial test of nicotine uptake determinations by multiple laboratories
R.J. Reynolds Tobacco Company, Human Studies Division, Winston-Salem, NC, USA
Total nicotine uptake by smokers is best determined by measuring nicotine and its major metabolites (usually five) in 24-h urine samples. Of additional interest is the primary metabolite cotinine in saliva since it is also related to total nicotine...