Bull. ARN, 2002, p. 55-69., ISSN.1146-6200
An eukariotic model based on the p53 tumour suppressor gene to estimate the mutagenic effect of tobacco smoke gazeous phase
CEA, CNRS - Lab. de Cancérogenèse Moléculaire, UMR 217 - DRR, DSV, CEA, FAR, Fontenay-aux-Roses, France
The tumour suppressor gene p53 encodes a protein whose major function is to protect the organism from the proliferation of potentially tumorigenic cells. Seventy per cent of the lung cancers display a mutation in the p53 gene. Statistical studies...