CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 05
Evaluation of a panel of potential gene biomarkers in two in vitro lung models following exposure to tobacco smoke and extracts
FIELDS W.R.(1,2); LIEDTKE W.(2); LI J.(2); BOMBICK B.R.(1)
(1) R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA; (2) Integrated Toxicology and Environmental Health Program, Duke University, Durham, NC 27710, USA
Lung cells are frequently used in in vitro studies to assess the impact of cigarette smoke on defense and repair mechanisms of the lung. Previously, we identified a panel of fifteen genes representing inflammation, oxidative stress, metabolism and...