CORESTA Congress, Edinburgh, 2010, AP 01; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 45
Nicotine is enantioselectively demethylated by cytochrome P450 enzyme CYP82E4
University of Kentucky, Dept. of Plant & Soil Sciences, Lexington, KY, USA
Nicotine and nornicotine are two of the dominant alkaloids found in tobacco (N. tabacum L.), and known precursors to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). In tobacco nicotine is N-demethylated to...