CORESTA Congress, Shanghai, 2008, AP 06
Reducing nicotine conversion: stability of RNAi-mediated and mutant down-regulation of nicotine demethylase
XU Dongmei; SHEN Yanxin; LUSSO M.; BAILEY A.; NORMAN D.; DAVIS G.; HART F.; CUI Mingwu; NIELSEN M.
U.S. Smokeless Tobacco Co., Winchester, KY, USA
Nornicotine, a secondary alkaloid formed from the demethylation of nicotine in tobacco, is the precursor of N'-nitrosonornicotine (NNN), a TSNA formed by nitrosation during tobacco curing. In earlier studies, we reported that GMO (RNAi) and non-GMO...