In the broad tobacco districts of Agrinion and Karditsa, the adaptability of cultivars of various oriental tobacco types was studied for three subsequent years (1982-84). The new cultivars were tall and multileaved compared to local shorter types with a lower number of larger (longer) leaves and thick midribs. The aim of this research was to find one or more cultivars suitable to substitute the lessmarketable types Tsembelia and Mavra. The research plan included cultivar comparison in the local Tobacco Research Stations and extensive farmers' tests. The agronomic characteristics and the chemical constitution of the cultivars tested were evaluated and compared among locations and years for each location. It was found that S 79, taste type oriental tobacco, can partially substitute these problematic types, if the appropriate cultural techniques (plant distances, fertilization) are practiced.