The Premarket Tobacco Product Application (PMTA) process for ENDS recommends that a wide range of Harmful and Potentially Harmful Compounds (HPHCs) be determined to support the application. The U.S. Food and Drug Administration provides guidance specifying a number of constituents and chemicals that should be included for analysis. However, no guidance is provided on appropriate analytical methodologies or test procedures. The present study was designed to assess methodologies for collection of aerosol samples for trace metals analysis. In this study, collection of ENDS aerosols on quartz filter pads (QF) was compared to electrostatic precipitation (EP). Specifically, the puffed room air blank measurements collected across a number of historical studies were analyzed and the resulting method limit of detection (LOD) values were computed using CORESTA Guide No. 28. QF and EP blank levels were compared across eight long-term stability studies for Chromium, Nickel, Cadmium, and Lead. Under QF collection virtually all the blank measurements levels, with the exception of Cd, were above the instrument LOD while under EP collection, virtually all the blank measurements levels were equal to the instrument LOD. The computed method LODs for QF and EP collection, respectively, were 0.68 ng and 0.37 ng for Cd, 130 ng and 7.6 ng (94 % reduced) for Cr, 43 ng and 3.7 ng (91 % reduced) for Ni, and 11 ng and 3.6 ng (66 % reduced) for Pb. This study confirms that using EP based aerosol collection for analytical measurements of trace metals in ENDS products significantly improves method detection limits for Cr, Ni, and Pb.