The experiment was carried out in the experimental Station of Zagreb Tobacco Institute, in Pitomaca, in 1987 and 1988. The cultivar Drava was fertilized with 0, 20, 40 and 60 kg/ha of nitrogen added in the fertilizer mixture NPK 6:14:22. Tobacco was irrigated depending on weather conditions : the first year by 250 mm of additional water, the following year by 200 mm. In both years, as the nitrogen rate increased from 0 to 60 kg/ha, average yield and length and wide of middle leaf also increased, but the visually estimated quality of cured leaf decreased. In comparison with non-fertilized tobacco, tobacco fertilized with 60 kg/ha of nitrogen differed in regard to the above mentioned parameters by ca 18%, 10%, 12% and 14% in 1987, and in the following year by ca 25%, 6%, 2% and 9%, respectively. At the same time, with increased fertilization, nicotine content increased and reducing sugar content decreased. The nitrogen rate of 60 kg/ha gave 15% and 32% lower reducing sugars in comparison to non-fertilized tobacco in 1987. In 1988, both figures were 18%. Significantly higher yield (16%) was found only in 1987 as a result of irrigation and in both years, only a tendency of a better visually estimated quality of cured leaf (1987, 12% and 1988, 6%). In both years, significantly greater lenght (1987, 15% and 1988, 18%) and width (1987, 19% and 1988, 14%) of middle leaf was also found. Chemical analysis of cured tobacco leaf showed higher content of nicotine in non-irrigated tobacco (1987, 38% and 1988, 30%) and lower content of reducing sugars (1987, 17% and 1988, 15%). (Nitrogen. Potassium. Phosphorus )