Currently the most important foliar diseases of tobacco in North Carolina (NC) are target spot, caused by Rhizoctonia solani , and blue mold, caused by Peronospora tabacina . Reported problems caused by target spot have gradually increased in frequency; significant yield losses recorded in flue-cured tobacco during the 2004 and 2005 growing seasons. Blue mold is a continual problem every year in this region, and most burley tobacco varieties are highly susceptible to this disease. Availability of effective chemical treatments for preventing and managing these two diseases is crucial for production of tobacco in North Carolina. An emergency exemption for the use of Quadris flowable fungicide, an azoxystrobin compound, was granted in NC for 2 weeks in 2005. Previous trials have shown that this product, when applied at 6, 9, or 12 fl oz/A, provided superior control of target spot on flue-cured tobacco, and moderate control of blue mold on burley tobacco. However, weather flecking has been reported with the use of this product on burley tobacco grown in the mountains of NC. In 2005 application of Quadris in flue-cured tobacco in 2 locations did not demonstrate any weather flecking. Field trials will be conducted again during the 2006 growing season in multiple locations across the state with Quadris applications on both burley and flue-cured tobacco to document any phytotoxicity, as well as its efficacy against these two important foliar diseases.