Field trials were conducted in 2012-2014 to evaluate the effects of three rates (1, 2 and 4 kg a.i./ha) of MCW-2 (a.i. fluensulfone) on plant growth and yield, and populations of Root-lesion (RLN) (Pratylenchus penetrans) and Stunt (Tylenchorhynchus spp.) nematodes. The effectiveness of these treatments was compared to plants grown without soil fumigation and with soil fumigation using Chloropicrin 100 (a.i. chloropicrin 99.0%). The trials were conducted in fields with a history of high nematode populations. The flue-cured tobacco cultivar CT157 was used each year in the trials. The MCW-2 treatments were applied to the soil surface and incorporated to a 10-cm depth with a roto-tiller prior to transplanting. Precipitation occurred within 72 hours after MCW-2 incorporation. Combined data over the three years indicated that treatments did not have significant effects on topping height, leaf number at topping and eighth leaf width. The eighth leaf length, tip leaf measurements and bud percentage, were the highest for the Chloropicrin 100 treatment and similar among the MCW-2 treatments and the non-fumigated control. The eighth leaf area for the Chloropicrin 100 and the MCW-2, 1 and 4 kg a.i./ha treatments, were also similar. Yield, as plant dry weight, of the Chloropicrin 100 treatment was significantly greater than all other treatments. Yields for all MCW-2 treatments and the non-fumigated control were similar. RLN numbers were not affected by treatments, although a slight decrease in RLN numbers was found for the Chloropicrin 100 mid-season assessment, and a slight increase in the RLN late-season counts. Chloropicrin 100 lowered mid-season numbers of combined RLN and Stunt nematodes. These results indicate that overall, the MCW-2 in the manner and rates used, was ineffective at altering numbers of soil nematodes and in enhancing plant growth and yield. (Reprinted with permission)