The flue-cured tobacco area of the province of Jujuy, in the North-West of Argentina, is characteristic for its extreme diversity of soil types and microclimates. Due to their alluvial origin, soil show great variations of physical conditions (texture) as well as of chemical constitution (organic matter, N-P-K levels and pH). Although these soils significantly differ from typical sandy flue-cured soils, low in organic matter and pH, and therefore in other countries are not usually used for flue-cured production, the tobacco growers of Jujuy learned successfully to manage the atypical environment. A fertilization test program, annually carried out since 15 years, has often suggested the use of fertilizer mixtures, amidic and ammonium nitrogen, unusual for flue-cured tobacco. The possibility of manufacturing different fertilizer grades according to individual farmer' soil test in the blending plant of the Cooperativa de Tabacaleros de Jujuy, contributed to the fact that currently more than 60% of an average Jujuy flue-cured crops are of orange style, normally of pronounced ripeness, which have high demand at the international market. This paper gives data of different atypical Jujuy tobacco soils, it compares them with "normal" flue-cured soils and it discusses unusual fertilizers. It also shows the successful evolution of Jujuy's flue-cured tobacco, compared with a typical crops of ends of the 1970's.