In order to establish the influence of different levels of fertilization and moisture upon certain vegetation characteristics, chemical composition and combustibility of Oriental tobacco, researches were conducted in a greenhouse using Mitscherlich pots of 8 kg filled with a mixture of soil and sand, in the ratio 1:1. The following doses of nutritive elements expressed in g/pot (active ingredient) were used: N₀P₀K₀, N₁P₂K₂, N₂P₄K₄, N₄P₆K₆ and N₆P₈K₈. Three levels of moisture were tested: 30%, 50% and 75% of the water capacity of the nutritive mixture. The tests used two Oriental cultivars in parallel: Djebel 123 and Djebel M 83. The following conclusions were drawn from the tests: for cultivar Djebel 123, all the variants with the moisture of 75% water capacity of the pot (WCP) reached the stage of floral bud (from 6 to 28 days). The level of moisture of 75% WCP leads to a maximum average height of the plants of 155.0 cm (N₄P₆K₆) for cultivar Djebel 123 and 257.5 cm (N₁P₂K₂) for cultivar Djebel M 83. The average number of leaves per plant was up to 46.0 for cultivar Djebel 123 (N₄P₆K₆ and 75% moisture) and up to 62.3 for cultivar Djebel M 83 (N₂P₄K₄ and 75% moisture). A moisture of 75% WCP resulted in a maximum leaf length of 34 cm for cultivar Djebel 123 (N₄P₆K₆) and 31 cm for cultivar Djebel M 83 (N₆P₈K₈). Cultivar Djebel M 83 has a better capacity than cv. Djebel 123 to use the moisture and nutritive elements to increase the size of the leaves towards the end of the vegetation period in the field, resulting in substantial yield increases. High potassium doses, correlated with a moisture of 75% WCP, result in a better combustibility of tobacco, counterbalancing the negative effect of nitrogen. For both tested cultivars the accumulation of nicotine is higher when doses of nitrogen are increased and lower when soil moisture is increased. Cultivar Djebel M 83, less precocious, making a better use of the soil moisture and nitrogen, showed a higher content of albumines than that Djebel 123. The albumines were directly influenced by increasing doses of nitrogen and gradually diminished with increasing soil moisture. For both cultivars the content of carbon-hydrates increased with increased doses of nutritive elements and increased moisture, reaching a level of 20.16% for cultivar Djebel 123 and 22.39 % for cultivar Djebel M 83 (at 75 % moisture and fertilization with N₄P₆K₆).