CORESTA Meeting, Smoke Science/Product Technology, 2023, Cancun, ST 18
An adverse outcome pathway for oxidative stress in plaque formation
MAKENA P.(1); HASWELL L.(2); McEWAN M.(2); KEYSER B.M.(1); SMART D.(2); LEVERETTE R.(1); JORDEN K.(1); BREHENY D.(2); BAXTER S.A.(2)
(1) RAI Services Company, Winston Salem, NC, U.S.A.; (2) BAT Investments Limited, R&D Centre, Southampton, U.K.
Adverse outcome pathways (AOPs) have been developed as risk assessment tool for regulatory applications. These AOPs describe a logical mechanistic sequence of events, starting with a Molecular Initiating Event (MIE), and ultimately leading to a...