CORESTA Congress, Kyoto, 2004, SS 17
Initiation and promotion in the SHE cell transformation assay
British American Tobacco, Group R&D, Southampton, UK
The induction of transformation in Syrian hamster embryo (SHE) cells is a multifactorial process in comparison to endpoints induced in in vitro genotoxicity assays such as Ames, mouse lymphoma and cytogenetics. Furthermore, a number of non-genotoxic...