TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 019
Microfluidic small airway lung model for toxicity screening of tobacco products
MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
(1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
Physiologically relevant in vitro lung models are valuable tools to accurately assess the cytotoxicity of inhaled toxicants. Epithelial cells cultured in transwells do not accurately represent the cellular architecture, physiology, and fluidic shear...