Bull. ARN, 2005, p. 49-60., ISSN.1146-6200.
Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats
UMR CNRS 5541, Lab. de Neuropsychologie des Désadaptations, Université de Bordeaux, Bordeaux, France
Nicotine is the major neuroactive compound of tobacco which has by itself weak reinforcing properties. It is known that levels of the enzymes monoamine oxidase A and B (MAO-A and MAO-B) are reduced in platelets and brain of smokers, and that...