CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 51
Simultaneous measurement of cilia beat frequency, goblet cell hyperplasia and TEER endpoints in EpiAirway™-FT treated tissues may reveal underlying toxicity mechanisms in vitro
(1) Department of Genetic Toxicology, Covance Laboratories Ltd, Harrogate, U.K.; (2) Special Pathology Services, Covance Laboratories Limited, Harrogate, U.K.
The EpiAirway™-FT (full thickness) tissues (Mattek Corporation, Ashland, USA) contain tight junctions, ciliated and other bronchial cell types making it an ideal model for testing aerosolised substances in vitro. Toxicity is not a single endpoint but...