Tob. Sci., 1998, 42-07, p. 38-45, ISSN. 0082-4523
Molecular dosimetry of O6-methylguanine in the major organs of A/J mice following a single application of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
CHANG C.G.; LEE C.K.; BROWN B.G.; LINEBERRY J.W.; POLHILL J.B., V; D.J. DOOLITTLE
Dep. Physiology and Pharmacology, Bowman Gray School of Medicine, Winston-Salem, NC, USA; Division of Environmental and Molecular Toxicology, Research and Development, R.J. Reynolds Tobacco Co., Winston-Salem, NC, USA
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, has been reported to induce lung adenomas in A/J mice. The initial step in NNK-induced lung tumorigenesis is thought to be the formation of methylated DNA bases,...